Methods of obtaining active antisense compounds

Freier, Susan M.; Matveeva, Olga; Tsodikov, Alexander; Giddings, Michael C.; Wyatt, Jacqueline R.

Title: Methods of obtaining active antisense compounds

Patent · Tue Jun 19 00:00:00 EDT 2012

OSTI ID:1531738

Freier, Susan M.; Matveeva, Olga; Tsodikov, Alexander; Giddings, Michael C.; Wyatt, Jacqueline R.

Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense oligonucleotide activity are provided, as are motifs identified according to this method. Methods of selecting effective antisense oligonucleotide sequences and effective antisense target sequences are provided, as are sequences selected according to these methods. In other methods of the invention, oligonucleotides are designed to hybridize to target sequences containing one or more activity-enhancing motifs. Antisense oligonucleotides designed according to these methods are also provided.

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Research Organization:: Isis Phramaceuticals, Inc., Carlsbad, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG03-99ER62732

Assignee:: Isis Pharmaceuticals, Inc. (Carlsbad, CA)

Patent Number(s):: 8,202,982

Application Number:: 12/557,358

OSTI ID:: 1531738

Resource Relation:: Patent File Date: 2009-09-10

Country of Publication:: United States

Language:: English

References (18)

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