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Title: Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom

Patent ·
OSTI ID:1531589
; ; ;

The present invention provides a system of self-assembling peptide amphiphiles with an absolute net charge of 3 or greater whose design and function may be patterned after proteins involved in vertebrate mineralization or other tissue forming processes. This molecular system preferably consists of a hydrophobic hydrocarbon tail attached to a relatively hydrophilic peptide sequence. Self-assembly of this peptide amphiphile may be induced through pH variation, divalent ion addition, or dehydration. Variations of structural peptide sequences in the peptide amphiphile may enable the assembled nanofibers to be reversibly cross-linked for more or less structural stability, or may allow for control of the rate of self-assembly.

Research Organization:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-00ER45810
Assignee:
Northwestern University (Evanston, IL)
Patent Number(s):
7,534,761
Application Number:
10/645,304
OSTI ID:
1531589
Resource Relation:
Patent File Date: 2003-08-21
Country of Publication:
United States
Language:
English

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Cited By (15)

Aligned nanofibers and related methods of use patent December 2016
Aligned nanofibers and related methods of use patent July 2014
Heteropeptides useful for reducing nonspecific adsorption patent March 2014
Peptide-based scaffolds for cartilage regeneration and methods for their use patent May 2013
Self-assembly and mineralization of peptide-amphiphile nanofibers patent November 2010
Anti-angiogenic molecules, nanostructures and uses thereof patent October 2015
Targeted therapy for the prevention of restenosis in the cardiovascular system patent December 2016
Peptide amphiphiles having improved solubility and methods of using same patent December 2011
Self-assembly of peptide-amphiphile nanofibers under physiological conditions patent June 2010
Self-assembling peptide amphiphiles and related methods for growth factor delivery patent March 2012
Self-assembly of peptide-amphiphile nanofibers under physiological conditions patent November 2011
Composition and method for self-assembly and mineralization of peptide-amphiphiles patent February 2012
Synthesis and self-assembly of ABC triblock bola peptide amphiphiles patent March 2010
Self-assembling peptide amphiphiles and related methods for growth factor delivery patent November 2013
Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use patent December 2010

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