Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins
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October 2014 |
Structure-Based Design of Potent and Ligand-Efficient Inhibitors of CTX-M Class A β-Lactamase
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February 2012 |
beta-Lactamases in laboratory and clinical resistance.
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October 1995 |
Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates
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February 2018 |
Atomic Resolution Structures of CTX-M β-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability
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April 2005 |
Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter -Derived Cephalosporinase-7, a Unique Class C β-Lactamase
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November 2017 |
Inhibition of Acinetobacter -Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel β-Lactamase Inhibitors
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November 2017 |
Ten Years with New Delhi Metallo-β-lactamase-1 (NDM-1): From Structural Insights to Inhibitor Design
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November 2018 |
Overview of the CCP 4 suite and current developments
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March 2011 |
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance
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June 2014 |
Binding of (5 S )-Penicilloic Acid to Penicillin Binding Protein 3
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August 2013 |
Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum β-Lactamases
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December 2014 |
Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism
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August 2011 |
Targeting metallo-β-lactamase enzymes in antibiotic resistance
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July 2013 |
A New Covalent Inhibitor of Class C β-Lactamases Reveals Extended Active Site Specificity
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December 2015 |
Extended-Spectrum -Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat
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October 2001 |
New β-Lactamase Inhibitors in the Clinic
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June 2016 |
Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes
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June 2016 |
Structural Milestones in the Reaction Pathway of an Amide Hydrolase
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March 2002 |
Rh( iii )-Catalyzed directed C–H carbenoid coupling reveals aromatic bisphosphonates inhibiting metallo- and Serine-β-lactamases
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January 2018 |
β-Lactam/β-Lactamase Inhibitor Combinations: From Then to Now
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October 2014 |
A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design
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February 2018 |
Towards automated crystallographic structure refinement with phenix.refine
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March 2012 |
Molecular docking and ligand specificity in fragment-based inhibitor discovery
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March 2009 |
Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase
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July 2015 |
Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae
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October 2010 |
Three Decades of -Lactamase Inhibitors
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January 2010 |
Beta-lactamases and bacterial resistance to antibiotics
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May 1995 |
Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability
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June 2015 |
Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030
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January 2016 |
The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis
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December 2017 |
Hierarchical Docking of Databases of Multiple Ligand Conformations
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August 2005 |
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
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May 2007 |
The Bacteria Fight Back
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July 2008 |
ZINC − A Free Database of Commercially Available Compounds for Virtual Screening
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December 2004 |
Docking for fragment inhibitors of AmpC -lactamase
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April 2009 |
Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding
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July 2017 |
electronic Ligand Builder and Optimization Workbench ( eLBOW ): a tool for ligand coordinate and restraint generation
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September 2009 |
In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors
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January 2018 |
The continuing challenge of ESBLs
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October 2007 |
Scaling and assessment of data quality
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December 2005 |
What's new in antibiotic resistance? Focus on beta-lactamases
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June 2006 |
Cyclobutanone Analogues of β-Lactams Revisited: Insights into Conformational Requirements for Inhibition of Serine- and Metallo-β-Lactamases
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March 2010 |
First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase
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January 2019 |
Exploring the potential of boronic acids as inhibitors of OXA-24/40 β-lactamase: Boronic Acid Inhibitors of OXA-24/40
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February 2017 |
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
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September 2010 |
Identification of Products of Inhibition of GES-2 β-Lactamase by Tazobactam by X-ray Crystallography and Spectrometry
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April 2011 |
The Crystal Structure of Phosphonate-Inhibited d -Ala- d -Ala Peptidase Reveals an Analogue of a Tetrahedral Transition State † , ‡
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February 2003 |
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM
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March 2011 |
Plasmid-Mediated Carbapenem-Hydrolyzing β-Lactamase KPC in a Klebsiella pneumoniae Isolate from France
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October 2005 |
Crystal Structure of KPC-2: Insights into Carbapenemase Activity in Class A β-Lactamases † , ‡
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May 2007 |
Structural Basis for Progression toward the Carbapenemase Activity in the GES Family of β-Lactamases
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November 2012 |
Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition
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January 2017 |
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
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December 2009 |
Automated docking with grid-based energy evaluation
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May 1992 |
Reversible inhibitors of penicillinases
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January 1978 |
Emergence of KPC-Possessing Klebsiella pneumoniae in Brooklyn, New York: Epidemiology and Recommendations for Detection
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July 2005 |
Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2)
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April 2017 |
Features and development of Coot
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March 2010 |
Status report on carbapenemases: challenges and prospects
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May 2011 |
A functional classification scheme for beta-lactamases and its correlation with molecular structure
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June 1995 |
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases
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December 2017 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance
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August 2011 |
New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition
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July 2012 |
Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic
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January 2015 |
Iterative-build OMIT maps: map improvement by iterative model building and refinement without model bias
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April 2008 |
Boronic Acid Transition State Inhibitors Active against KPC and Other Class A β-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor Design
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January 2016 |
Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
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August 2016 |
Cyclobutanone Analogues of β-Lactam Antibiotics: β-Lactamase Inhibitors with Untapped Potential?
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February 2017 |
Crystal Structures of Penicillin-Binding Protein 6 from Escherichia coli
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October 2009 |
Fragment-based inhibitor discovery against β-lactamase
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March 2014 |
Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition
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November 2014 |
Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.
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October 1965 |
Mechanistic Basis for the Emergence of Catalytic Competence against Carbapenem Antibiotics by the GES Family of β-Lactamases
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October 2009 |
Phaser crystallographic software
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July 2007 |
2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases
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October 2012 |
Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234
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April 2018 |