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Title: Biomechanical Feedback Strengthens Jammed Cellular Packings

Abstract

Growth in confined spaces can drive cellular populations through a jamming transition from a fluidlike state to a solidlike state. Experiments have found that jammed budding yeast populations can build up extreme compressive pressures (over 1 MPa), which in turn feed back onto cellular physiology by slowing or even stalling cell growth. Using numerical simulations, we investigate how this feedback impacts the mechanical properties of model jammed cell populations. We find that feedback directs growth toward poorly coordinated regions, resulting in an excess number of cell-cell contacts that rigidify cell packings. Cell packings possess anomalously large shear and bulk moduli that depend sensitively on the strength of feedback. These results demonstrate that mechanical feedback on the single-cell level is a simple mechanism by which living systems may tune their population-level mechanical properties.

Authors:
 [1];  [1];  [1]
  1. Univ. of California, Berkeley, CA (United States). Dept. of Physics and Integrative Biology
Publication Date:
Research Org.:
Lawrence Berkeley National Laboratory-National Energy Research Scientific Computing Center (NERSC)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1527126
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Journal Article
Journal Name:
Physical Review Letters
Additional Journal Information:
Journal Volume: 122; Journal Issue: 20; Journal ID: ISSN 0031-9007
Country of Publication:
United States
Language:
English

Citation Formats

Gniewek, Pawel, Schreck, Carl F., and Hallatschek, Oskar. Biomechanical Feedback Strengthens Jammed Cellular Packings. United States: N. p., 2019. Web. doi:10.1103/PhysRevLett.122.208102.
Gniewek, Pawel, Schreck, Carl F., & Hallatschek, Oskar. Biomechanical Feedback Strengthens Jammed Cellular Packings. United States. doi:10.1103/PhysRevLett.122.208102.
Gniewek, Pawel, Schreck, Carl F., and Hallatschek, Oskar. Wed . "Biomechanical Feedback Strengthens Jammed Cellular Packings". United States. doi:10.1103/PhysRevLett.122.208102.
@article{osti_1527126,
title = {Biomechanical Feedback Strengthens Jammed Cellular Packings},
author = {Gniewek, Pawel and Schreck, Carl F. and Hallatschek, Oskar},
abstractNote = {Growth in confined spaces can drive cellular populations through a jamming transition from a fluidlike state to a solidlike state. Experiments have found that jammed budding yeast populations can build up extreme compressive pressures (over 1 MPa), which in turn feed back onto cellular physiology by slowing or even stalling cell growth. Using numerical simulations, we investigate how this feedback impacts the mechanical properties of model jammed cell populations. We find that feedback directs growth toward poorly coordinated regions, resulting in an excess number of cell-cell contacts that rigidify cell packings. Cell packings possess anomalously large shear and bulk moduli that depend sensitively on the strength of feedback. These results demonstrate that mechanical feedback on the single-cell level is a simple mechanism by which living systems may tune their population-level mechanical properties.},
doi = {10.1103/PhysRevLett.122.208102},
journal = {Physical Review Letters},
issn = {0031-9007},
number = 20,
volume = 122,
place = {United States},
year = {2019},
month = {5}
}

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