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Title: Dynamical Self-Assembly: Constrained phase separation and mesoscale dynamics in lipid membranes (Final Report)

Technical Report ·
DOI:https://doi.org/10.2172/1525891· OSTI ID:1525891
ORCiD logo [1]; ORCiD logo [2];  [1];  [1];  [1];  [1];  [1];  [1];  [2];  [2];  [2];  [3];  [4];  [5];  [5];  [6];  [7];  [2];  [8]
  1. Univ. of California, Davis, CA (United States)
  2. Univ. of California, San Diego, CA (United States)
  3. Sandia National Lab. (SNL-CA), Livermore, CA (United States)
  4. Northern Illinois Univ., DeKalb, IL (United States)
  5. Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
  6. Linkoping Univ. (Sweden); Sweden Tech. Univ. (Sweden); Nanyang Tech. Univ. (Singapore)
  7. Nanyang Tech. Univ. (Singapore)
  8. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
+ Show Author Affiliations

This final technical report summarizes scientific and technical achievements derived through the the award, DE-FG02-04ER46173 [2013-2016, 2016-2017, and 2017-2018(NCE)], for the grant proposal titled, “Dynamical Self-Assembly: Constrained phase separation and mesoscale dynamics in lipid membranes.” The effort was organized into three major scientific aims: (1) characterize the mechanism of inter-layer coupling of laterally phase-separated domains in stacked lipid bilayers; (2) characterize curvature-dependent dynamic reorganization in membrane milieu; and (3) characterize real-time effects of mechanochemical perturbations on lateral phase separation membrane bilayers. The cumulative weight of the activities, including experimental research and collaborative modeling, disseminated through the publications listed above and presentations, has addressed two over-arching objectives: (a) to abstract a physical science based understanding of fundamental rules that determine dynamic self-assembly processes in lipid bilayer membranes - a versatile class of biologically inspired interfacial complex fluids and (b) to translate these physical principles into quantitative design rules for the development of new classes of membrane-based complex materials that exhibit complex, co-operative, and adaptive behavior.

Research Organization:
Univ. of California, Davis, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Materials Sciences & Engineering Division
DOE Contract Number:
FG02-04ER46173
OSTI ID:
1525891
Report Number(s):
DOE-UCDAVIS-46173
Resource Relation:
Related Information: see below
Country of Publication:
United States
Language:
English

References (18)

Cholesterol Partition and Condensing Effect in Phase-Separated Ternary Mixture Lipid Multilayers journal March 2016
Oscillatory phase separation in giant lipid vesicles induced by transmembrane osmotic differentials journal October 2014
Third-Party ATP Sensing in Polymersomes: A Label-Free Assay of Enzyme Reactions in Vesicular Compartments journal August 2013
Cholesterol-Enriched Domain Formation Induced by Viral-Encoded, Membrane-Active Amphipathic Peptide journal January 2016
Lipid Membrane Deformation Accompanied by Disk-to-Ring Shape Transition of Cholesterol-Rich Domains journal July 2015
Continuity of Monolayer-Bilayer Junctions for Localization of Lipid Raft Microdomains in Model Membranes journal May 2016
Lithographically Defined Macroscale Modulation of Lateral Fluidity and Phase Separation Realized via Patterned Nanoporous Silica-Supported Phospholipid Bilayers journal October 2013
Thermal Annealing Triggers Collapse of Biphasic Supported Lipid Bilayers into Multilayer Islands journal April 2014
Mixing, Diffusion, and Percolation in Binary Supported Membranes Containing Mixtures of Lipids and Amphiphilic Block Copolymers journal July 2014
Accurate calibration and control of relative humidity close to 100% by X-raying a DOPC multilayer journal January 2015
Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes journal October 2018
Mixing Water, Transducing Energy, and Shaping Membranes: Autonomously Self-Regulating Giant Vesicles journal February 2016
Interaction of sphingomyelinase with sphingomyelin-containing supported membranes journal January 2013
Role of Squalene in the Organization of Monolayers Derived from Lipid Extracts of Halobacterium salinarum journal June 2013
Lipid Membrane Domains for the Selective Adsorption and Surface Patterning of Conjugated Polyelectrolytes journal April 2013
Biologically inspired far-from-equilibrium materials journal February 2019
On-Demand Self-Assembly of Supported Membranes Using Sacrificial, Anhydrobiotic Sugar Coats journal December 2013
Medium Matters: Order through Fluctuations? journal June 2015

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Related Subjects

36 MATERIALS SCIENCE
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
bio-inspired materials
structure and dynamics in soft matter
organization under non-equilibrium conditions
phase separation
self-assembly
membrane-mimetic materials