Altered amplitude of low‐frequency fluctuation in basal ganglia correlates to pulmonary ventilation function in COPD patients: A resting‐state fMRI study

Journal Article · Wed May 29 00:00:00 EDT 2019 · Brain and Behavior (Online)

DOI:https://doi.org/10.1002/brb3.1336· OSTI ID:1523303

Lu, Chun‐Qiang ^[1]; Xu, Weiwei ^[1]; Zeng, Chu‐Hui ^[1]; Ge, Lu‐Yao ^[2]; Wang, Yuan‐Cheng ^[1]; Meng, Xiang‐Pan ^[1]; Yu, Qian ^[1]; Wu, Di ^[1]; Ju, Shenghong  ^[1]

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1. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology Zhongda Hospital, Medical School of Southeast University Nanjing China
2. Department of Respirology Zhongda Hospital, Medical School of Southeast University Nanjing China

Abstract Introduction Patients under chronic obstructive pulmonary disease (COPD) has been reported to be associated with a higher prevalence of cognitive impairment (CI). However, it is still largely unknown whether the aberrant resting‐state spontaneous neuronal activity pattern reflected by the amplitude of low‐frequency fluctuation (ALFF) analysis will be associated with the CI in COPD patients. Materials A total of 28 COPD patients and 26 healthy controls were enrolled in this study. Of all the subjects, structural and functional MRI data, spirometry tests performance and neuropsychological assessments of different cognitive domains were collected. Voxel‐based two‐sample t tests were used to detect brain regions showing differences in the ALFF value between COPD patients and healthy controls. An additional fMRI runs with supplementary oxygen delivery were employed to explore the impact of elevated partial pressure of oxygen (PaO ₂ ) or moderate hyperoxia on ALFF in COPD patients and healthy controls respectively. Results More extensive white matter lesion was detected in COPD patients. COPD patients exhibit decreased ALFF value in bilateral basal ganglia areas and right thalamus, and aberrant ALFF value is correlated with PaO ₂ and pulmonary ventilation function (FEV1%pred). COPD patients performed worse in the Digit Span Test (reverse), Digit Symbol Substitution Test, Trail‐making test (A and B) than controls. After supplementary oxygen inhalation, the ALFF value of basal ganglia and right thalamus significantly increased in the controls, but not in the COPD patients. Conclusions COPD patients mainly exhibit impaired executive function but not long‐term memory in cognitive function assessment. Aberrant ALFF alteration in the deep brain may be directly related to lower PaO ₂ in COPD patients.

• Sponsoring Organization: USDOE
• OSTI ID: 1523303
• Alternate ID(s): OSTI ID: 1523306
• Journal Information: Brain and Behavior (Online), Journal Name: Brain and Behavior (Online) Vol. 9 Journal Issue: 7; ISSN 2162-3279
• Publisher: Wiley Blackwell (John Wiley & Sons)
• Country of Publication: United States
• Language: English