skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Simultaneous inversion of shear modulus and traction boundary conditions in biomechanical imaging

Journal Article · · Inverse Problems in Science and Engineering

We present a formulation to simultaneously invert for a heterogeneous shear modulus field and traction boundary conditions in an incompressible linear elastic plane stress model. Our approach utilizes scalable deterministic methods, including adjoint-based sensitivities and quasi-Newton optimization, to reduce the computational requirements for large-scale inversion with partial differential equation (PDE) constraints. Here, we address the use of regularization for such formulations and explore the use of different types of regularization for the shear modulus and boundary traction. We apply this PDE-constrained optimization algorithm to a synthetic dataset to verify the accuracy in the reconstructed parameters, and to experimental data from a tissue-mimicking ultrasound phantom. In all of these examples, we compare inversion results from full-field and sparse data measurements.

Research Organization:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
ExxonMobil CRADA; USDOE
Grant/Contract Number:
AC04-94AL85000
OSTI ID:
1515211
Report Number(s):
SAND-2019-4125J; 674645
Journal Information:
Inverse Problems in Science and Engineering, Vol. 28, Issue 2; ISSN 1741-5977
Publisher:
Taylor & FrancisCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 5 works
Citation information provided by
Web of Science

References (45)

On the limited memory BFGS method for large scale optimization journal August 1989
Three-dimensional ultrasound imaging
  • Prager, R. W.; Ijaz, U. Z.; Gee, A. H.
  • Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, Vol. 224, Issue 2 https://doi.org/10.1243/09544119JEIM586
journal November 2009
Finite Element Analysis of Some Inverse Elasticity Problems journal June 1989
Biomechanical imaging of cell stiffness and prestress with subcellular resolution journal September 2013
Linear and nonlinear elasticity imaging of soft tissue in vivo : demonstration of feasibility journal January 2009
Force traction microscopy: An inverse problem with pointwise observations journal November 2012
Quantitative three-dimensional elasticity imaging from quasi-static deformation: a phantom study journal January 2009
Large scale parameter estimation problems in frequency-domain elastodynamics using an error in constitutive equation functional journal January 2013
Iterative Methods for Total Variation Denoising journal January 1996
Cell traction force and measurement methods journal January 2007
A numerical method for the inverse problem of cell traction in 3D journal August 2012
Three-dimensional Ultrasound Elasticity Imaging on an Automated Breast Volume Scanning System journal May 2017
Solution of inverse problems in elasticity imaging using the adjoint method journal February 2003
Updating quasi-Newton matrices with limited storage journal September 1980
Algorithms for quantitative quasi-static elasticity imaging using force data: ALGORITHMS FOR QUANTITATIVE QUASI-STATIC ELASTICITY IMAGING
  • Tyagi, Mohit; Goenezen, Sevan; Barbone, Paul E.
  • International Journal for Numerical Methods in Biomedical Engineering, Vol. 30, Issue 12 https://doi.org/10.1002/cnm.2665
journal August 2014
Traction patterns of tumor cells journal April 2008
Investigation of regularization parameters and error estimating in inverse elasticity problems journal March 1994
Model-based elastography: a survey of approaches to the inverse elasticity problem journal January 2012
High Resolution Traction Force Microscopy Based on Experimental and Computational Advances journal January 2008
Simultaneous identification of unknown groundwater pollution sources and estimation of aquifer parameters journal September 2009
Bayesian estimation of heat flux and thermal diffusivity using liquid crystal thermography journal January 2015
Cellular Traction as an Inverse Problem journal January 2006
A nonlinear elasticity phantom containing spherical inclusions journal July 2012
Direct error in constitutive equation formulation for plane stress inverse elasticity problem journal February 2017
Simultaneous estimation of spatially dependent diffusion coefficient and source term in a nonlinear 1D diffusion problem journal July 2004
Simultaneous Inverse Identification of Transient Thermal Properties and Heat Sources Using Sparse Sensor Information journal December 2007
Simultaneous parameter estimation and contaminant source characterization for coupled groundwater flow and contaminant transport modelling journal July 1992
Efficient determination of multiple regularization parameters in a generalized L-curve framework journal July 2002
Inferring spatial variations of microstructural properties from macroscopic mechanical response journal September 2016
Modified error in constitutive equations (MECE) approach for ultrasound elastography journal October 2017
Regularization Parameter Selection for Nonlinear Iterative Image Restoration and MRI Reconstruction Using GCV and SURE-Based Methods journal August 2012
Recovery of cellular traction in three-dimensional nonlinear hyperelastic matrices journal February 2017
Quantitative Compression Optical Coherence Elastography as an Inverse Elasticity Problem journal May 2016
An overview of the Trilinos project journal September 2005
Inverse problems in elasticity journal February 2005
A fast hybrid algorithm combining regularized motion tracking and predictive search for reducing the occurrence of large displacement errors journal April 2011
Computational Methods for Inverse Problems book January 2002
A Newton-CG method for large-scale three-dimensional elastic full-waveform seismic inversion journal May 2008
Towards the mechanical characterization of abdominal wall by inverse analysis journal February 2017
Simultaneous optical flow and source estimation: Space–time discretization and preconditioning journal October 2015
Visualizing the Stress Distribution Within Vascular Tissues Using Intravascular Ultrasound Elastography: A Preliminary Investigation journal June 2015
High Resolution Forward And Inverse Earthquake Modeling on Terascale Computers conference January 2003
Simultaneous full‐waveform inversion for source wavelet and earth model conference October 2009
Multiparameter material model and source signature full waveform inversion conference May 2011
Three-dimensional ultrasound imaging journal January 2005