Impact of Enzyme Motion on Activity †
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journal
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November 2002 |
Flexibility, Diversity, and Cooperativity: Pillars of Enzyme Catalysis
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journal
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December 2011 |
Catalytic Efficiency of Enzymes: A Theoretical Analysis
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journal
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December 2012 |
Prediction of distal residue participation in enzyme catalysis: Distal Residue Participation in Enzyme Catalysis
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journal
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April 2015 |
Dynamically Achieved Active Site Precision in Enzyme Catalysis
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journal
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December 2014 |
Picosecond-Resolved Fluorescent Probes at Functionally Distinct Tryptophans within a Thermophilic Alcohol Dehydrogenase: Relationship of Temperature-Dependent Changes in Fluorescence to Catalysis
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journal
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June 2014 |
Identification of a Long-range Protein Network That Modulates Active Site Dynamics in Extremophilic Alcohol Dehydrogenases
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journal
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March 2013 |
Remote Mutations Alter Transition-State Structure of Human Purine Nucleoside Phosphorylase †
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journal
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February 2008 |
Remote Mutations and Active Site Dynamics Correlate with Catalytic Properties of Purine Nucleoside Phosphorylase
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journal
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May 2008 |
Protein Dynamics in Enzymatic Catalysis: Exploration of Dihydrofolate Reductase
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journal
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January 2000 |
Evidence for a Functional Role of the Dynamics of Glycine-121 of Escherichia coli Dihydrofolate Reductase Obtained from Kinetic Analysis of a Site-Directed Mutant †
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journal
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December 1997 |
Network of coupled promoting motions in enzyme catalysis
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journal
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February 2002 |
Coupling Interactions of Distal Residues Enhance Dihydrofolate Reductase Catalysis: Mutational Effects on Hydride Transfer Rates †
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journal
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October 2002 |
Effect of Mutation on Enzyme Motion in Dihydrofolate Reductase
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journal
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April 2003 |
The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase
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journal
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July 2006 |
Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase
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journal
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April 2005 |
A Distal Mutation Perturbs Dynamic Amino Acid Networks in Dihydrofolate Reductase
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journal
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June 2013 |
Catalytic Contributions from Remote Regions of Enzyme Structure
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journal
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December 2011 |
Connecting Protein Conformational Dynamics with Catalytic Function As Illustrated in Dihydrofolate Reductase
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journal
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January 2013 |
Protein Mass-Modulated Effects in the Catalytic Mechanism of Dihydrofolate Reductase: Beyond Promoting Vibrations
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journal
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May 2014 |
Extension and Limits of the Network of Coupled Motions Correlated to Hydride Transfer in Dihydrofolate Reductase
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journal
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January 2014 |
Simulations of remote mutants of dihydrofolate reductase reveal the nature of a network of residues coupled to hydride transfer
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journal
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May 2014 |
Network of Remote and Local Protein Dynamics in Dihydrofolate Reductase Catalysis
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journal
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March 2015 |
Active Site and Remote Contributions to Catalysis in Methylthioadenosine Nucleosidases
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journal
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April 2015 |
Automated identification of functional dynamic contact networks from X-ray crystallography
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journal
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August 2013 |
Energetics and Dynamics of Enzymatic Reactions
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journal
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August 2001 |
Temporally Overlapped but Uncoupled Motions in Dihydrofolate Reductase Catalysis
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journal
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July 2013 |
Update 1 of: Tunneling and Dynamics in Enzymatic Hydride Transfer
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journal
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December 2010 |
Role of Dynamics in Enzyme Catalysis: Substantial versus Semantic Controversies
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journal
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December 2014 |
Protein Dynamics and Enzymatic Chemical Barrier Passage
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journal
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December 2011 |
Conformational changes and catalysis by alcohol dehydrogenase
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journal
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January 2010 |
Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis
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journal
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June 1993 |
A link between protein structure and enzyme catalyzed hydrogen tunneling
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journal
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November 1997 |
Probes of Hydrogen Tunneling with Horse Liver Alcohol Dehydrogenase at Subzero Temperatures †
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journal
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February 2001 |
Contributions of Valine-292 in the Nicotinamide Binding Site of Liver Alcohol Dehydrogenase and Dynamics to Catalysis † , ‡
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journal
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October 2001 |
Barrier passage and protein dynamics in enzymatically catalyzed reactions: Barrier passage and protein dynamics
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journal
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July 2002 |
Identification of a Protein-Promoting Vibration in the Reaction Catalyzed by Horse Liver Alcohol Dehydrogenase
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journal
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April 2002 |
Rate constants for a mechanism including intermediates in the interconversion of ternary complexes by horse liver alcohol dehydrogenase
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journal
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May 1990 |
Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 Å resolution
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journal
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March 1981 |
Crystallographic investigations of nicotinamide adenine dinucleotide binding to horse liver alcohol dehydrogenase
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journal
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December 1984 |
Hydride Transfer in Liver Alcohol Dehydrogenase: Quantum Dynamics, Kinetic Isotope Effects, and Role of Enzyme Motion
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journal
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November 2001 |
Anticorrelated motions as a driving force in enzyme catalysis: The dehydrogenase reaction
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journal
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August 2004 |
Low-frequency normal modes in horse liver alcohol dehydrogenase and motions of residues involved in the enzymatic reaction
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journal
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March 2007 |
Protein Promoting Vibrations in Enzyme CatalysisA Conserved Evolutionary Motif
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journal
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May 2003 |
A Computational Method to Identify Residues Important in Creating a Protein Promoting Vibration in Enzymes
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journal
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January 2003 |
Yeast Alcohol Dehydrogenase Structure and Catalysis
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journal
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September 2014 |
Another Look at the Mechanisms of Hydride Transfer Enzymes with Quantum and Classical Transition Path Sampling
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journal
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March 2015 |
Enzymatic Kinetic Isotope Effects from First-Principles Path Sampling Calculations
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journal
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March 2016 |
Changes in Protein Architecture and Subpicosecond Protein Dynamics Impact the Reaction Catalyzed by Lactate Dehydrogenase
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journal
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March 2013 |
Structurally Linked Dynamics in Lactate Dehydrogenases of Evolutionarily Distinct Species
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journal
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May 2017 |
Substitutions of isoleucine residues at the adenine binding site activate horse liver alcohol dehydrogenase
|
journal
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April 1995 |
Amino Acid Residues in the Nicotinamide Binding Site Contribute to Catalysis by Horse Liver Alcohol Dehydrogenase † , ‡
|
journal
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March 2003 |
Effects of Cavities at the Nicotinamide Binding Site of Liver Alcohol Dehydrogenase on Structure, Dynamics and Catalysis
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journal
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January 2014 |
A 21st century revisionist's view at a turning point in enzymology
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journal
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July 2009 |
Elusive transition state of alcohol dehydrogenase unveiled
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journal
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May 2010 |
Substitutions in a Flexible Loop of Horse Liver Alcohol Dehydrogenase Hinder the Conformational Change and Unmask Hydrogen Transfer † , ‡
|
journal
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October 1999 |
A Remote Mutation Affects the Hydride Transfer by Disrupting Concerted Protein Motions in Thymidylate Synthase
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journal
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October 2012 |
Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR
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journal
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January 2014 |
Prediction of solvent accessibility and sites of deleterious mutations from protein sequence
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journal
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June 2005 |
Similar Hydrophobic Replacements of Leu99 and Phe153 within the Core of T4 Lysozyme Have Different Structural and Thermodynamic Consequences
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journal
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February 1993 |
Repacking the Core of T4 Lysozyme by Automated Design
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journal
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September 2003 |
Energetics of aliphatic deletions in protein cores
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journal
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August 2006 |
Lessons from the lysozyme of phage T4
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journal
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January 2010 |
Hydrogen-Exchange Stabilities of RNase T1 and Variants with Buried and Solvent-Exposed Ala → Gly Mutations in the Helix †
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journal
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December 1999 |
Protein conformational stabilities can be determined from hydrogen exchange rates
- Scholtz, J. Martin; Pace, C. Nick; Huyghues-Despointes, Beatrice M. P.
-
Nature Structural Biology, Vol. 6, Issue 10, p. 910-912
https://doi.org/10.1038/13273
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journal
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October 1999 |
Clusters of isoleucine, leucine, and valine side chains define cores of stability in high-energy states of globular proteins: Sequence determinants of structure and stability: BASiC Clusters-Stability Cores of Proteins
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journal
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December 2015 |
Dynamic Coupling and Allosteric Behavior in a Nonallosteric Protein †
|
journal
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June 2006 |
Progressive sequence alignment and molecular evolution of the Zn-containing alcohol dehydrogenase family
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journal
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June 1992 |
Effects of point mutations in a hinge region on the stability, folding, and enzymic activity of Escherichia coli dihydrofolate reductase
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journal
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August 1991 |
Computational and Theoretical Methods to Explore the Relation between Enzyme Dynamics and Catalysis
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journal
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August 2006 |
Atomic-Resolution Structures of Horse Liver Alcohol Dehydrogenase with NAD + and Fluoroalcohols Define Strained Michaelis Complexes
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journal
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May 2012 |
Expression and Kinetic Characterization of Recombinant Human Stomach Alcohol Dehydrogenase: ACTIVE-SITE AMINO ACID SEQUENCE EXPLAINS SUBSTRATE SPECIFICITY COMPARED WITH LIVER ISOZYMES
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journal
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February 1995 |
Origins of the high catalytic activity of human alcohol dehydrogenase 4 studied with horse liver A317C alcohol dehydrogenase
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journal
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May 2011 |
Product Inhibition Studies on Yeast and Liver Alcohol Dehydrogenases *
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journal
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September 1963 |
The kinetics of enzyme-catalyzed reactions with two or more substrates or products
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journal
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January 1963 |
Deprotonation of the Horse Liver Alcohol Dehydrogenase−NAD + Complex Controls Formation of the Ternary Complexes †
|
journal
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September 2005 |
Evidence for site equivalence in the reaction mechanism of horse liver alcohol dehydrogenase with aromatic substrates at alkaline pH
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journal
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June 1977 |
Site-site interactions in the liver alcohol dehydrogenase catalytic mechanism
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journal
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May 1979 |
Probes of a Role for Remote Binding Interactions on Hydrogen Tunneling in the Horse Liver Alcohol Dehydrogenase Reaction †
|
journal
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February 2000 |
Activation of Horse Liver Alcohol Dehydrogenase upon Substitution of Tryptophan 314 at the Dimer Interface
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journal
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October 1998 |
Refolding and Reactivation of Liver Alcohol Dehydrogenase after Dissociation and Denaturation in 6M Guanidine Hydrochloride
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journal
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July 1978 |
Effect of Zinc(II) on the Refolding and Reactivation of Liver Alcohol Dehydrogenase
|
journal
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July 1978 |
Kinetics of native and activated isozymes of horse liver alcohol dehydrogenase
|
journal
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January 1977 |
Effects of urea and guanidine hydrochloride on the activity and the dynamical structure of equine liver alcohol dehydrogenase
|
journal
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May 1986 |
Loop and Subdomain Movements in the Mechanism of Escherichia coli Dihydrofolate Reductase: Crystallographic Evidence † , ‡
|
journal
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January 1997 |
Barriers to Hydride Transfer in Wild Type and Mutant Dihydrofolate Reductase from E. c oli
|
journal
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December 2003 |
The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase
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journal
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July 2004 |
Effects of a Distal Mutation on Active Site Chemistry †
|
journal
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February 2006 |
Barrier crossing in dihydrofolate reductase does not involve a rate-promoting vibration
|
journal
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May 2012 |
A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis
|
journal
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April 2011 |
Evidence that a ‘dynamic knockout’ in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis
|
journal
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March 2012 |
Active Site Modifications in a Double Mutant of Liver Alcohol Dehydrogenase: Structural Studies of Two Enzyme−Ligand Complexes † , ‡
|
journal
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June 1998 |
The Linear Dependence of Log(kcat/Km) for Reduction of NAD+ by PhCH2OH on the Distance between Reactants when Catalyzed by Horse Liver Alcohol Dehydrogenase and 203 Single Point Mutants
|
journal
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August 1999 |
An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling
|
journal
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March 2009 |
Effects of the Donor–Acceptor Distance and Dynamics on Hydride Tunneling in the Dihydrofolate Reductase Catalyzed Reaction
|
journal
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January 2012 |
Free Energy Simulations of Active-Site Mutants of Dihydrofolate Reductase
|
journal
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August 2014 |
A Theoretical Analysis of the Proton and Hydride Transfer in Liver Alcohol Dehydrogenase (LADH)
|
journal
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March 2002 |
Fast Protein Motions Are Coupled to Enzyme H-Transfer Reactions
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journal
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February 2013 |
Macromolecular TLS Refinement in REFMAC at Moderate Resolutions
|
book
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January 2003 |
Dynamic Structures of Horse Liver Alcohol Dehydrogenase (HLADH): Results of Molecular Dynamics Simulations of HLADH-NAD + -PhCH 2 OH, HLADH-NAD + -PhCH 2 O - , and HLADH-NADH-PhCHO
|
journal
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December 2001 |
Structures of Horse Liver Alcohol Dehydrogenase Complexed with NAD+ and Substituted Benzyl Alcohols
|
journal
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May 1994 |
Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis
|
journal
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January 1986 |
5′–3′ Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis
|
journal
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January 1988 |
Free R value: a novel statistical quantity for assessing the accuracy of crystal structures
|
journal
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January 1992 |
Improved methods for building protein models in electron density maps and the location of errors in these models
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journal
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March 1991 |
Studies on liver alcohol dehydrogenase complexes
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journal
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January 1964 |