Proceedings of the ISEV symposium on “HIV, NeuroAIDS, drug abuse &amp; EVs”

Hu, Guoku; Witwer, Kenneth W.; Bond, Vincent C.; Haughey, Norman; Kashanchi, Fatah; Pulliam, Lynn; Buch, Shilpa

doi:10.1080/20013078.2017.1294360

Proceedings of the ISEV symposium on “HIV, NeuroAIDS, drug abuse & EVs”

Journal Article · Thu Nov 30 23:00:00 EST 2017 · Journal of Extracellular Vesicles

DOI:https://doi.org/10.1080/20013078.2017.1294360· OSTI ID:1510348

Hu, Guoku ^[1]; Witwer, Kenneth W. ^[2]; Bond, Vincent C. ^[3]; Haughey, Norman ^[4]; Kashanchi, Fatah ^[5]; Pulliam, Lynn ^[6]; ^[1]

Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center Omaha NE USA
Department of Molecular and Comparative Pathobiology Johns Hopkins University School of Medicine Baltimore MD USA
Department of Microbiology Biochemistry, and Immunology Morehouse School of Medicine Atlanta GA USA
Department of Neurology the Johns Hopkins University School of Medicine Baltimore MD USA, Department of Psychiatry the Johns Hopkins University School of Medicine Baltimore MD USA
Laboratory of Molecular Virology School of Systems Biology George Mason University Manassas VA USA
Departments of Laboratory Medicine and Medicine University of California San Francisco San Francisco CA USA

ABSTRACT

Extracellular vesicles (EVs) are globular, membrane bound nanovesicles (30–100 nm range) that are shed both during normal cellular functioning and under pathological conditions by most cell types. In recent years, there has been significant interest in the study of these vesicles as conduits for the delivery of information between cells from both analogous and disparate tissues. Their ability to carry specialised cargo including signalling mediators, proteins, messenger RNA and miRNAs characterises these vesicles as primary facilitators of cell‐to‐cell communication and regulation. EVs have also been demonstrated to play important roles in the field of cancer biology and metastasis. However, significant knowledge gaps exist in the role these vesicles play in the context of HIV infection and drug abuse. To foster discussion in this area a satellite symposium on “HIV, NeuroAIDS, Drug Abuse & EVs”, was held in conjunction with the annual meeting of the International Society for Extracellular Vesicles (ISEV) in Bethesda, in April 2015. Experts in HIV and drug abuse fields were invited to share their findings on the role of EVs in HIV‐1 infection and drug addiction. Additional discussion included current areas of research in EV biology in HIV infection and drug abuse.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0001599; SC0001599

OSTI ID:: 1510348

Journal Information:: Journal of Extracellular Vesicles, Journal Name: Journal of Extracellular Vesicles Journal Issue: 1 Vol. 6; ISSN 2001-3078

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

References (43)

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids Théry, Clotilde; Amigorena, Sebastian; Raposo, Graça Current Protocols in Cell Biology, Vol. 30, Issue 1 https://doi.org/10.1002/0471143030.cb0322s30	journal	March 2006
Microvesicles Are a Source of Contaminating Cellular Proteins Found in Purified HIV-1 Preparations Bess, Julian W.; Gorelick, Robert J.; Bosche, William J. Virology, Vol. 230, Issue 1 https://doi.org/10.1006/viro.1997.8499	journal	March 1997
Purification of HIV-1 Virions by Subtilisin Digestion or CD45 Immunoaffinity Depletion for Biochemical Studies Ott, David E. Methods in Molecular Biology https://doi.org/10.1007/978-1-59745-170-3_2	book	January 2008
Exosomes and their role in CNS viral infections Sampey, Gavin C.; Meyering, Shabana S.; Asad Zadeh, Mohammad Journal of NeuroVirology, Vol. 20, Issue 3 https://doi.org/10.1007/s13365-014-0238-6	journal	February 2014
Exfoliation of membrane ecto-enzymes in the form of micro-vesicles Trams, Eberhard G.; Lauter, Carl J.; Norman Salem, Jr. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 645, Issue 1 https://doi.org/10.1016/0005-2736(81)90512-5	journal	June 1981
The Biological Significance of the Thromboplastic Protein of Blood Chargaff, Erwin; West, Randolph Journal of Biological Chemistry, Vol. 166, Issue 1 https://doi.org/10.1016/S0021-9258(17)34997-9	journal	November 1946
Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). Johnstone, R. M.; Adam, M.; Hammond, J. R. Journal of Biological Chemistry, Vol. 262, Issue 19 https://doi.org/10.1016/S0021-9258(18)48095-7	journal	July 1987
Exosomes – vesicular carriers for intercellular communication Simons, Mikael; Raposo, Graça Current Opinion in Cell Biology, Vol. 21, Issue 4 https://doi.org/10.1016/j.ceb.2009.03.007	journal	August 2009
Discrimination between exosomes and HIV-1: Purification of both vesicles from cell-free supernatants Cantin, Réjean; Diou, Juliette; Bélanger, Dave Journal of Immunological Methods, Vol. 338, Issue 1-2 https://doi.org/10.1016/j.jim.2008.07.007	journal	September 2008
Inflammatory responses in the rat brain in response to different methods of intra-cerebral administration McCluskey, Lisa; Campbell, Sandra; Anthony, Daniel Journal of Neuroimmunology, Vol. 194, Issue 1-2 https://doi.org/10.1016/j.jneuroim.2007.11.009	journal	February 2008
Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord Campbell, Sandra J.; Zahid, Imran; Losey, Patrick Neuropharmacology, Vol. 55, Issue 5 https://doi.org/10.1016/j.neuropharm.2008.06.074	journal	October 2008
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators Staels, Bart; Koenig, Wolfgang; Habib, Aïda Nature, Vol. 393, Issue 6687 https://doi.org/10.1038/31701	journal	June 1998
Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: A mechanism for cellular human immunodeficiency virus 1 infection Mack, Matthias; Kleinschmidt, Andrea; Brühl, Hilke Nature Medicine, Vol. 6, Issue 7 https://doi.org/10.1038/77498	journal	July 2000
Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated Neuronal dysfunction Hu, G.; Yao, H.; Chaudhuri, A. D. Cell Death & Disease, Vol. 3, Issue 8 https://doi.org/10.1038/cddis.2012.114	journal	August 2012
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Valadi, Hadi; Ekström, Karin; Bossios, Apostolos Nature Cell Biology, Vol. 9, Issue 6 https://doi.org/10.1038/ncb1596	journal	May 2007
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers Skog, Johan; Würdinger, Tom; van Rijn, Sjoerd Nature Cell Biology, Vol. 10, Issue 12 https://doi.org/10.1038/ncb1800	journal	November 2008
Exosomes: composition, biogenesis and function Théry, Clotilde; Zitvogel, Laurence; Amigorena, Sebastian Nature Reviews Immunology, Vol. 2, Issue 8 https://doi.org/10.1038/nri855	journal	August 2002
Functional delivery of viral miRNAs via exosomes Pegtel, D. M.; Cosmopoulos, K.; Thorley-Lawson, D. A. Proceedings of the National Academy of Sciences, Vol. 107, Issue 14 https://doi.org/10.1073/pnas.0914843107	journal	March 2010
The Trojan exosome hypothesis Gould, S. J.; Booth, A. M.; Hildreth, J. E. K. Proceedings of the National Academy of Sciences, Vol. 100, Issue 19 https://doi.org/10.1073/pnas.1831413100	journal	August 2003
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Kliewer, S. A.; Forman, B. M.; Blumberg, B. Proceedings of the National Academy of Sciences, Vol. 91, Issue 15 https://doi.org/10.1073/pnas.91.15.7355	journal	July 1994
Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA Sampey, Gavin C.; Saifuddin, Mohammed; Schwab, Angela Journal of Biological Chemistry, Vol. 291, Issue 3 https://doi.org/10.1074/jbc.M115.662171	journal	November 2015
Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes Pan, B. T. The Journal of Cell Biology, Vol. 101, Issue 3 https://doi.org/10.1083/jcb.101.3.942	journal	September 1985
Vesicles Associated with Calcification in the Matrix of Epiphyseal Cartilage Anderson, H. C. The Journal of Cell Biology, Vol. 41, Issue 1 https://doi.org/10.1083/jcb.41.1.59	journal	April 1969
B lymphocytes secrete antigen-presenting vesicles Raposo, G. Journal of Experimental Medicine, Vol. 183, Issue 3 https://doi.org/10.1084/jem.183.3.1161	journal	March 1996
Modulation of Cellular Function Through Immune-Activated Exosomes Pulliam, Lynn; Gupta, Archana DNA and Cell Biology, Vol. 34, Issue 7 https://doi.org/10.1089/dna.2015.2884	journal	July 2015
CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury Campbell, Sandra J.; Hughes, Paula M.; Iredale, John P. The FASEB Journal, Vol. 17, Issue 9 https://doi.org/10.1096/fj.02-0757fje	journal	June 2003
Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-κB in endothelial cells Tang, Norina; Sun, Bing; Gupta, Archana The FASEB Journal, Vol. 30, Issue 9 https://doi.org/10.1096/fj.201600368RR	journal	September 2016
The Systemic and Local Acute Phase Response following Acute Brain Injury Wilcockson, David C.; Campbell, Sandra J.; Anthony, Daniel C. Journal of Cerebral Blood Flow & Metabolism, Vol. 22, Issue 3 https://doi.org/10.1097/00004647-200203000-00009	journal	March 2002
Cytokine-induced Acute Inflammation in the Brain and Spinal Cord Schnell, L.; Fearn, S.; Schwab, M. E. Journal of Neuropathology and Experimental Neurology, Vol. 58, Issue 3 https://doi.org/10.1097/00005072-199903000-00004	journal	January 1999
The Nature and Significance of Platelet Products in Human Plasma Wolf, Peter British Journal of Haematology, Vol. 13, Issue 3 https://doi.org/10.1111/j.1365-2141.1967.tb08741.x	journal	May 1967
The Isolation of Tobacco ring spot and Other Virus Proteins by Ultracentrifugation Stanley, W. M.; Wyckoff, R. W. G. Science, Vol. 85, Issue 2198 https://doi.org/10.1126/science.85.2198.181	journal	February 1937
Highly Purified Human Immunodeficiency Virus Type 1 Reveals a Virtual Absence of Vif in Virions Dettenhofer, Markus; Yu, Xiao-Fang Journal of Virology, Vol. 73, Issue 2 https://doi.org/10.1128/JVI.73.2.1460-1467.1999	journal	February 1999
The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor alpha in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes Vega, R. B.; Huss, J. M.; Kelly, D. P. Molecular and Cellular Biology, Vol. 20, Issue 5 https://doi.org/10.1128/MCB.20.5.1868-1876.2000	journal	March 2000
Macrophage microvesicles induce macrophage differentiation and miR-223 transfer Ismail, Noura; Wang, Yijie; Dakhlallah, Duaa Blood, Vol. 121, Issue 6 https://doi.org/10.1182/blood-2011-08-374793	journal	February 2013
Exosomes as mediators of neuroinflammation Gupta, Archana; Pulliam, Lynn Journal of Neuroinflammation, Vol. 11, Issue 1 https://doi.org/10.1186/1742-2094-11-68	journal	January 2014
The role of PPAR activation during the systemic response to brain injury Losey, Patrick; Ladds, Emma; Laprais, Maud Journal of Neuroinflammation, Vol. 12, Issue 1 https://doi.org/10.1186/s12974-015-0295-7	journal	May 2015
Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense Hu, Guoku; Gong, Ai-Yu; Roth, Amanda L. PLoS Pathogens, Vol. 9, Issue 4 https://doi.org/10.1371/journal.ppat.1003261	journal	April 2013
HIV-Associated Neurological Disorders: A Guide to Pharmacotherapy Tan, Ik L.; McArthur, Justin C. CNS Drugs, Vol. 26, Issue 2 https://doi.org/10.2165/11597770-000000000-00000	journal	January 2012
Ultrastructural Localization of the Prostasome - an Organelle in Human Seminal Plasma Brody, Isser; Ronquist, Gunnar; Gottfries, Arvid Upsala Journal of Medical Sciences, Vol. 88, Issue 2 https://doi.org/10.3109/03009738309178440	journal	January 1983
Exosomal miRNAs: Biological Properties and Therapeutic Potential Hu, Guoku; Drescher, Kristen M.; Chen, Xian-Ming Frontiers in Genetics, Vol. 3 https://doi.org/10.3389/fgene.2012.00056	journal	January 2012
Extracellular vesicles from infected cells: potential for direct pathogenesis Schwab, Angela; Meyering, Shabana S.; Lepene, Ben Frontiers in Microbiology, Vol. 6 https://doi.org/10.3389/fmicb.2015.01132	journal	October 2015
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research Witwer, Kenneth W.; Buzás, Edit I.; Bemis, Lynne T. Journal of Extracellular Vesicles, Vol. 2, Issue 1 https://doi.org/10.3402/jev.v2i0.20360	journal	January 2013
Membrane vesicles shed by murine melanoma cells selectively inhibit the expression of Ia antigen by macrophages. Poutsiaka, D. D.; Schroder, E. W.; Taylor, D. D. The Journal of Immunology, Vol. 134, Issue 1 https://doi.org/10.4049/jimmunol.134.1.138	journal	January 1985

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