Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)

Hamid, Ahmed M.; Prabhakaran Nair Syamala Amma, Aneesh; Garimella, Venkata BS; Ibrahim, Yehia M.; Smith, Richard D.

doi:10.1016/j.ijms.2018.03.006

Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)

Journal Article · 01 July 2018 · International Journal of Mass Spectrometry

DOI:https://doi.org/10.1016/j.ijms.2018.03.006· OSTI ID:1510271

Hamid, Ahmed M. ^[1]; Prabhakaran Nair Syamala Amma, Aneesh ^[1]; ^[1]; ^[1]; ^[1]

BATTELLE (PACIFIC NW LAB)

Ion mobility (IM) is rapidly gaining attention for the analysis of biomolecules due to the ability to distinguish the shapes of ions. However, conventional constant electric field drift tube IM has limited resolving power, constrained by practical limitations on the path length and maximum applied voltage. The implementation of traveling waves (TW) in IM removes the latter limitation, allowing higher resolution to be achieved using extended path lengths. These can be readily obtainable in structures for lossless ion manipulations (SLIM), which are fabricated from electric fields that are generated by appropriate potentials applied to arrays of electrodes patterned on two parallel surfaces. In this work we have investigated the relationship between the various SLIM variables, such as electrode dimensions, inter-surface gap, and the TW applied voltages, that directly impact the fields experienced by ions. Ion simulation and theoretical calculations have been utilized to understand the dependence of SLIM geometry and effective electric field. The variables explored impact both ion confinement and the observed IM resolution in Structures for Lossless Ion Manipulations (SLIM) modules.

Research Organization:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1510271

Report Number(s):: PNNL-SA-127372

Journal Information:: International Journal of Mass Spectrometry, Vol. 430

Country of Publication:: United States

Language:: English

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Recommendations for reporting ion mobility Mass Spectrometry measurements No authors listed Mass Spectrometry Reviews https://doi.org/10.1002/mas.21585		October 2017
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