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Characterization of a Novel Covlent Monoadduct on the RNA Overhang of an RNA-DNA Hybrid Induced by Antitumor Antibiotic Neocarzinostatin

Journal Article · · Biochemistry
DOI:https://doi.org/10.1021/bi972659w· OSTI ID:1509871
 [1];  [2];  [1];  [3];  [4]
  1. Harvard Medical School
  2. ASSOC WESTERN UNIVERSITY
  3. BATTELLE (PACIFIC NW LAB)
  4. Harvard University
+ Show Author Affiliations

Neocarzinostatin chromophore (NCS-chrom) has been found previously to induce thiol-dependent abasic site formation and cleavage on the RNA strand of RNA - DNA hybrids.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
OSTI ID:
1509871
Report Number(s):
PNNL-SA-30185
Journal Information:
Biochemistry, Journal Name: Biochemistry Journal Issue: 6 Vol. 37
Country of Publication:
United States
Language:
English

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Related Subjects

neocarzinostatin
covalent monoadduct
hybrid induced
antitumor antibiotic