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Title: High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies

Journal Article · · mAbs
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  1. Department of Antibody Engineering, Genentech Inc., South San Francisco, USA
  2. Structural Biology, Genentech Inc., South San Francisco, USA
  3. Translational Oncology, Genentech Inc., South San Francisco, USA
  4. Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, USA
  5. Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, USA
  6. Cancer Immunology, Genentech Inc., South San Francisco, USA
+ Show Author Affiliations

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
National Institutes of Health (NIH)
OSTI ID:
1506504
Journal Information:
mAbs, Vol. 11, Issue 1; ISSN 1942-0862
Country of Publication:
United States
Language:
ENGLISH

References (47)

Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule journal December 1986
Broad tumor-associated expression and recognition by tumor-derived    T cells of MICA and MICB journal June 1999
Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands journal May 2007
Enhancing full-length antibody production by signal peptide engineering journal March 2016
Statistical distribution of amino acid sequences: a proof of Darwinian evolution journal October 2010
Refinement of Macromolecular Structures by the Maximum-Likelihood Method journal May 1997
Overview of the CCP 4 suite and current developments journal March 2011
Crystal Structure of the MHC Class I Homolog MIC-A, a γδ T Cell Ligand journal May 1999
Population study of allelic diversity in the human MHC class I-related MIC-A gene journal June 1999
MICA polymorphism in a northern Chinese Han population: The identification of a new MICA allele, MICA*059 journal April 2010
Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies journal October 2015
Effects of glycosylation on the stability of protein pharmaceuticals journal April 2009
Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines journal July 2013
Features and development of Coot journal March 2010
Diversity of MICA and Linkage Disequilibrium with HLA-B in Two North American Populations journal March 2006
Optimization and automation of an end-to-end high throughput microscale transient protein production process: Optimization of an Automated Microscale Transient Expression System journal July 2015
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation journal October 2002
Correlation between sequence hydrophobicity and surface-exposure pattern of database proteins journal February 2004
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex journal April 2004
Development of a semi-automated high throughput transient transfection system journal June 2014
Tumor-Associated MICA Is Shed by ADAM Proteases journal August 2008
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab journal February 2003
Cross-Reactivity of T Cells and Its Role in the Immune System journal January 2012
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA journal July 1999
Expression of full-length immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies journal May 2002
Complex structure of the activating immunoreceptor NKG2D and its MHC class I–like ligand MICA journal May 2001
The making of bispecific antibodies journal December 2016
Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing journal March 2017
Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941 journal May 2009
Alternative molecular formats and therapeutic applications for bispecific antibodies journal October 2015
Optimizing antibody expression by using the naturally occurring framework diversity in a live bacterial antibody display system journal December 2015
Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity journal June 2006
Hydroxyl Radical-Mediated Modification of Proteins as Probes for Structural Proteomics journal August 2007
Study of MICA alleles in 201 African Americans by multiplexed single nucleotide extension (MSNE) typing journal January 2003
Structure-based Comparative Analysis and Prediction of N-linked Glycosylation Sites in Evolutionarily Distant Eukaryotes journal April 2013
Obstructing Shedding of the Immunostimulatory MHC Class I Chain-Related Gene B Prevents Tumor Formation journal January 2009
Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies journal July 2013
An Improved Fast Photochemical Oxidation of Proteins (FPOP) Platform for Protein Therapeutics journal December 2014
Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding journal October 2002
Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies journal April 2010
An six-amino acid motif in the α3 domain of MICA is the cancer therapeutic target to inhibit shedding journal September 2009
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Effect of glycosylation on protein folding: A close look at thermodynamic stabilization journal June 2008
Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity journal March 2018
Expansion of the ISWI chromatin remodeler family with new active complexes journal August 2017
Enhancing antibody patent protection using epitope mapping information journal December 2017

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