Collective motion conceals fitness differences in crowded cellular populations

Kayser, Jona; Schreck, Carl F.; Gralka, Matti; Fusco, Diana; Hallatschek, Oskar

doi:10.1038/s41559-018-0734-9

Title: Collective motion conceals fitness differences in crowded cellular populations

Journal Article · Mon Dec 03 00:00:00 EST 2018 · Nature Ecology and Evolution

DOI:https://doi.org/10.1038/s41559-018-0734-9· OSTI ID:1506392

Kayser, Jona ^[1]; Schreck, Carl F. ^[1]; Gralka, Matti ^[1]; Fusco, Diana ^[1];

^[1]

Univ. of California, Berkeley, CA (United States). Dept. of Physics, and Dept. of Integrative Biology

Many cellular populations are tightly packed, such as microbial colonies and biofilms, or tissues and tumours in multicellular organisms. The movement of one cell in these crowded assemblages requires motion of others, so that cell displacements are correlated over many cell diameters. Whenever movement is important for survival or growth, these correlated rearrangements could couple the evolutionary fate of different lineages. However, little is known about the interplay between mechanical forces and evolution in dense cellular populations. Here, by tracking slower-growing clones at the expanding edge of yeast colonies, we show that the collective motion of cells prevents costly mutations from being weeded out rapidly. Joint pushing by neighbouring cells generates correlated movements that suppress the differential displacements required for selection to act. This mechanical screening of fitness differences allows slower-growing mutants to leave more descendants than expected under non-mechanical models, thereby increasing their chance for evolutionary rescue. Our work suggests that, in crowded populations, cells cooperate with surrounding neighbours through inevitable mechanical interactions. This effect has to be considered when predicting evolutionary outcomes, such as the emergence of drug resistance or cancer evolution.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Science Foundation (NSF); National Institutes of Health (NIH)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1506392

Journal Information:: Nature Ecology and Evolution, Vol. 3, Issue 1; ISSN 2397-334X

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 16 works

Citation information provided by
Web of Science

References (88)

Clonal interference and Mullerʼs ratchet in spatial habitats Otwinowski, Jakub; Krug, Joachim Physical Biology, Vol. 11, Issue 5 https://doi.org/10.1088/1478-3975/11/5/056003	journal	August 2014
A comparison of jamming behavior in systems composed of dimer- and ellipse-shaped particles Schreck, Carl F.; Xu, Ning; O'Hern, Corey S. Soft Matter, Vol. 6, Issue 13 https://doi.org/10.1039/c001085e	journal	January 2010
Genetic Consequences of Range Expansions Excoffier, Laurent; Foll, Matthieu; Petit, Rémy J. Annual Review of Ecology, Evolution, and Systematics, Vol. 40, Issue 1 https://doi.org/10.1146/annurev.ecolsys.39.110707.173414	journal	December 2009
Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer Lamprecht, Sebastian; Schmidt, Eva Marina; Blaj, Cristina Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-00976-9	journal	November 2017
Spatial Population Expansion Promotes the Evolution of Cooperation in an Experimental Prisoner’s Dilemma Van Dyken, J. David; Müller, Melanie J. I.; Mack, Keenan M. L. Current Biology, Vol. 23, Issue 10 https://doi.org/10.1016/j.cub.2013.04.026	journal	May 2013
Spatial structure, cooperation and competition in biofilms Nadell, Carey D.; Drescher, Knut; Foster, Kevin R. Nature Reviews Microbiology, Vol. 14, Issue 9 https://doi.org/10.1038/nrmicro.2016.84	journal	July 2016
Multicellularity makes somatic differentiation evolutionarily stable Wahl, Mary E.; Murray, Andrew W. Proceedings of the National Academy of Sciences, Vol. 113, Issue 30 https://doi.org/10.1073/pnas.1608278113	journal	July 2016
Evolutionary rescue in a changing world Carlson, Stephanie M.; Cunningham, Curry J.; Westley, Peter A. H. Trends in Ecology & Evolution, Vol. 29, Issue 9 https://doi.org/10.1016/j.tree.2014.06.005	journal	September 2014
The rate at which asexual populations cross fitness valleys Weissman, Daniel B.; Desai, Michael M.; Fisher, Daniel S. Theoretical Population Biology, Vol. 75, Issue 4 https://doi.org/10.1016/j.tpb.2009.02.006	journal	June 2009
Ecological systems biology: The dynamics of interacting populations Friedman, Jonathan; Gore, Jeff Current Opinion in Systems Biology, Vol. 1 https://doi.org/10.1016/j.coisb.2016.12.001	journal	February 2017
Scaling of Traction Forces with the Size of Cohesive Cell Colonies Mertz, Aaron F.; Banerjee, Shiladitya; Che, Yonglu Physical Review Letters, Vol. 108, Issue 19 https://doi.org/10.1103/PhysRevLett.108.198101	journal	May 2012
Emergence of Spatial Structure in Cell Groups and the Evolution of Cooperation Nadell, Carey D.; Foster, Kevin R.; Xavier, João B. PLoS Computational Biology, Vol. 6, Issue 3 https://doi.org/10.1371/journal.pcbi.1000716	journal	March 2010
Evolutionary rescue can prevent extinction following environmental change Bell, Graham; Gonzalez, Andrew Ecology Letters, Vol. 12, Issue 9 https://doi.org/10.1111/j.1461-0248.2009.01350.x	journal	September 2009
The morphology of Saccharomyces cerevisiae colonies is affected by cell adhesion and the budding pattern Vopálenská, Irena; Hůlková, Marta; Janderová, Blanka Research in Microbiology, Vol. 156, Issue 9 https://doi.org/10.1016/j.resmic.2005.05.012	journal	November 2005
Evolutionary rescue from extinction is contingent on a lower rate of environmental change Lindsey, Haley A.; Gallie, Jenna; Taylor, Susan Nature, Vol. 494, Issue 7438 https://doi.org/10.1038/nature11879	journal	February 2013
Mechanical interactions in bacterial colonies and the surfing probability of beneficial mutations Farrell, Fred D.; Gralka, Matti; Hallatschek, Oskar Journal of The Royal Society Interface, Vol. 14, Issue 131 https://doi.org/10.1098/rsif.2017.0073	journal	June 2017
Life at the Front of an Expanding Population Hallatschek, Oskar; Nelson, David R. Evolution, Vol. 64, Issue 1 https://doi.org/10.1111/j.1558-5646.2009.00809.x	journal	January 2010
The Influence of Cell Mechanics, Cell-Cell Interactions, and Proliferation on Epithelial Packing Farhadifar, Reza; Röper, Jens-Christian; Aigouy, Benoit Current Biology, Vol. 17, Issue 24 https://doi.org/10.1016/j.cub.2007.11.049	journal	December 2007
Localized cell death focuses mechanical forces during 3D patterning in a biofilm Asally, M.; Kittisopikul, M.; Rue, P. Proceedings of the National Academy of Sciences, Vol. 109, Issue 46 https://doi.org/10.1073/pnas.1212429109	journal	September 2012
Self-driven jamming in growing microbial populations Delarue, Morgan; Hartung, Jörn; Schreck, Carl Nature Physics, Vol. 12, Issue 8 https://doi.org/10.1038/nphys3741	journal	May 2016
Mechanically Driven Growth of Quasi-Two-Dimensional Microbial Colonies Farrell, F. D. C.; Hallatschek, O.; Marenduzzo, D. Physical Review Letters, Vol. 111, Issue 16 https://doi.org/10.1103/PhysRevLett.111.168101	journal	October 2013
On the accumulation of deleterious mutations during range expansions Peischl, S.; Dupanloup, I.; Kirkpatrick, M. Molecular Ecology, Vol. 22, Issue 24 https://doi.org/10.1111/mec.12524	journal	November 2013
Radial Domany-Kinzel models with mutation and selection Lavrentovich, Maxim O.; Korolev, Kirill S.; Nelson, David R. Physical Review E, Vol. 87, Issue 1 https://doi.org/10.1103/PhysRevE.87.012103	journal	January 2013
Genetic drift at expanding frontiers promotes gene segregation Hallatschek, O.; Hersen, P.; Ramanathan, S. Proceedings of the National Academy of Sciences, Vol. 104, Issue 50 https://doi.org/10.1073/pnas.0710150104	journal	December 2007
Physical interactions reduce the power of natural selection in growing yeast colonies Giometto, Andrea; Nelson, David R.; Murray, Andrew W. Proceedings of the National Academy of Sciences, Vol. 115, Issue 45 https://doi.org/10.1073/pnas.1809587115	journal	October 2018
Surfing during population expansions promotes genetic revolutions and structuration Excoffier, Laurent; Ray, Nicolas Trends in Ecology & Evolution, Vol. 23, Issue 7 https://doi.org/10.1016/j.tree.2008.04.004	journal	July 2008
Antibiotic resistance and its cost: is it possible to reverse resistance? Andersson, Dan I.; Hughes, Diarmaid Nature Reviews Microbiology, Vol. 8, Issue 4 https://doi.org/10.1038/nrmicro2319	journal	March 2010
Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion Yan, Jing; Nadell, Carey D.; Stone, Howard A. Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-00401-1	journal	August 2017
Founder takes all: density-dependent processes structure biodiversity Waters, Jonathan M.; Fraser, Ceridwen I.; Hewitt, Godfrey M. Trends in Ecology & Evolution, Vol. 28, Issue 2 https://doi.org/10.1016/j.tree.2012.08.024	journal	February 2013
Genetic drift and selection in many-allele range expansions Weinstein, Bryan T.; Lavrentovich, Maxim O.; Möbius, Wolfram PLOS Computational Biology, Vol. 13, Issue 12 https://doi.org/10.1371/journal.pcbi.1005866	journal	December 2017
Turning ecology and evolution against cancer Korolev, Kirill S.; Xavier, Joao B.; Gore, Jeff Nature Reviews Cancer, Vol. 14, Issue 5 https://doi.org/10.1038/nrc3712	journal	April 2014
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues Lambert, Guillaume; Estévez-Salmeron, Luis; Oh, Steve Nature Reviews Cancer, Vol. 11, Issue 5 https://doi.org/10.1038/nrc3039	journal	April 2011
Shape of the growing front of biofilms Wang, Xin; Stone, Howard A.; Golestanian, Ramin New Journal of Physics, Vol. 19, Issue 12 https://doi.org/10.1088/1367-2630/aa983f	journal	December 2017
Spatially Constrained Growth Enhances Conversional Meltdown Lavrentovich, Maxim O.; Wahl, Mary E.; Nelson, David R. Biophysical Journal, Vol. 110, Issue 12 https://doi.org/10.1016/j.bpj.2016.05.024	journal	June 2016
Vibrio cholerae biofilm growth program and architecture revealed by single-cell live imaging Yan, Jing; Sharo, Andrew G.; Stone, Howard A. Proceedings of the National Academy of Sciences, Vol. 113, Issue 36 https://doi.org/10.1073/pnas.1611494113	journal	August 2016
The Competitive Cost of Antibiotic Resistance in Mycobacterium tuberculosis Gagneux, S. Science, Vol. 312, Issue 5782 https://doi.org/10.1126/science.1124410	journal	June 2006
Spatial structure increases the waiting time for cancer Martens, Erik A.; Kostadinov, Rumen; Maley, Carlo C. New Journal of Physics, Vol. 13, Issue 11 https://doi.org/10.1088/1367-2630/13/11/115014	journal	November 2011
Allele surfing promotes microbial adaptation from standing variation Gralka, Matti; Stiewe, Fabian; Farrell, Fred Ecology Letters, Vol. 19, Issue 8 https://doi.org/10.1111/ele.12625	journal	June 2016
Diffusion-limited growth in bacterial colony formation Matsushita, Mitsugu; Fujikawa, Hiroshi Physica A: Statistical Mechanics and its Applications, Vol. 168, Issue 1 https://doi.org/10.1016/0378-4371(90)90402-E	journal	September 1990
Fiji: an open-source platform for biological-image analysis Schindelin, Johannes; Arganda-Carreras, Ignacio; Frise, Erwin Nature Methods, Vol. 9, Issue 7 https://doi.org/10.1038/nmeth.2019	journal	June 2012
Saccharomyces cerevisiae colony growth and ageing: biphasic growth accompanied by changes in gene expression Meunier, Jean-Roch; Choder, Mordechai Yeast, Vol. 15, Issue 12 https://doi.org/10.1002/(SICI)1097-0061(19990915)15:12<1159::AID-YEA441>3.0.CO;2-D	journal	September 1999
Knowing the Boundaries: Extending the Differential Adhesion Hypothesis in Embryonic Cell Sorting Amack, J. D.; Manning, M. L. Science, Vol. 338, Issue 6104 https://doi.org/10.1126/science.1223953	journal	October 2012
Spatial organization of the extracellular matrix regulates cell-cell junction positioning Tseng, Q.; Duchemin-Pelletier, E.; Deshiere, A. Proceedings of the National Academy of Sciences, Vol. 109, Issue 5 https://doi.org/10.1073/pnas.1106377109	journal	January 2012
Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments Fusco, Diana; Gralka, Matti; Kayser, Jona Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms12760	journal	October 2016
How structured yeast multicellular communities live, age and die? Váchová, Libuše; Palková, Zdena FEMS Yeast Research, Vol. 18, Issue 4 https://doi.org/10.1093/femsyr/foy033	journal	March 2018
The differential adhesion hypothesis: a direct evaluation Foty, Ramsey A.; Steinberg, Malcolm S. Developmental Biology, Vol. 278, Issue 1 https://doi.org/10.1016/j.ydbio.2004.11.012	journal	February 2005
How Linear Tension Converts to Curvature: Geometric Control of Bone Tissue Growth Bidan, Cécile M.; Kommareddy, Krishna P.; Rumpler, Monika PLoS ONE, Vol. 7, Issue 5 https://doi.org/10.1371/journal.pone.0036336	journal	May 2012
Selective sweeps in growing microbial colonies Korolev, Kirill S.; Müller, Melanie J. I.; Karahan, Nilay Physical Biology, Vol. 9, Issue 2 https://doi.org/10.1088/1478-3975/9/2/026008	journal	April 2012
Spatiotemporal microbial evolution on antibiotic landscapes Baym, M.; Lieberman, T. D.; Kelsic, E. D. Science, Vol. 353, Issue 6304 https://doi.org/10.1126/science.aag0822	journal	September 2016
Cell morphology drives spatial patterning in microbial communities Smith, William P. J.; Davit, Yohan; Osborne, James M. Proceedings of the National Academy of Sciences, Vol. 114, Issue 3 https://doi.org/10.1073/pnas.1613007114	journal	December 2016
A Quantitative Test of Population Genetics Using Spatiogenetic Patterns in Bacterial Colonies Korolev, Kirill S.; Xavier, João B.; Nelson, David R. The American Naturalist, Vol. 178, Issue 4 https://doi.org/10.1086/661897	journal	October 2011
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation Bertet, Claire; Sulak, Lawrence; Lecuit, Thomas Nature, Vol. 429, Issue 6992 https://doi.org/10.1038/nature02590	journal	June 2004
Coaction of intercellular adhesion and cortical tension specifies tissue surface tension Manning, M. Lisa; Foty, Ramsey A.; Steinberg, Malcolm S. Proceedings of the National Academy of Sciences, Vol. 107, Issue 28 https://doi.org/10.1073/pnas.1003743107	journal	June 2010
Memory and Fitness Optimization of Bacteria under Fluctuating Environments Lambert, Guillaume; Kussell, Edo PLoS Genetics, Vol. 10, Issue 9 https://doi.org/10.1371/journal.pgen.1004556	journal	September 2014
Genetic drift opposes mutualism during spatial population expansion Muller, M. J. I.; Neugeboren, B. I.; Nelson, D. R. Proceedings of the National Academy of Sciences, Vol. 111, Issue 3 https://doi.org/10.1073/pnas.1313285111	journal	January 2014
Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis Lecuit, Thomas; Lenne, Pierre-François Nature Reviews Molecular Cell Biology, Vol. 8, Issue 8 https://doi.org/10.1038/nrm2222	journal	August 2007
A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity Waclaw, Bartlomiej; Bozic, Ivana; Pittman, Meredith E. Nature, Vol. 525, Issue 7568 https://doi.org/10.1038/nature14971	journal	August 2015
A Big Bang model of human colorectal tumor growth Sottoriva, Andrea; Kang, Haeyoun; Ma, Zhicheng Nature Genetics, Vol. 47, Issue 3 https://doi.org/10.1038/ng.3214	journal	February 2015
Collective and single cell behavior in epithelial contact inhibition Puliafito, A.; Hufnagel, L.; Neveu, P. Proceedings of the National Academy of Sciences, Vol. 109, Issue 3 https://doi.org/10.1073/pnas.1007809109	journal	January 2012
Fluidization of tissues by cell division and apoptosis Ranft, J.; Basan, M.; Elgeti, J. Proceedings of the National Academy of Sciences, Vol. 107, Issue 49 https://doi.org/10.1073/pnas.1011086107	journal	November 2010
Reply: Is the evolution of tumors Darwinian or non-Darwinian? Williams, Marc J.; Werner, Benjamin; Barnes, Chris P. National Science Review, Vol. 5, Issue 1 https://doi.org/10.1093/nsr/nwx131	journal	January 2018
Phase transition in the collective migration of tissue cells: Experiment and model Szabó, B.; Szöllösi, G. J.; Gönci, B. Physical Review E, Vol. 74, Issue 6 https://doi.org/10.1103/physreve.74.061908	journal	December 2006
Self-Organization in High-Density Bacterial Colonies: Efficient Crowd Control Cho, HoJung; Jönsson, Henrik; Campbell, Kyle PLoS Biology, Vol. 5, Issue 11 https://doi.org/10.1371/journal.pbio.0050302	journal	October 2007
Fungal Biofilms Fanning, Saranna; Mitchell, Aaron P. PLoS Pathogens, Vol. 8, Issue 4 https://doi.org/10.1371/journal.ppat.1002585	journal	April 2012
Accumulation of Deleterious Mutations During Bacterial Range Expansions Bosshard, Lars; Dupanloup, Isabelle; Tenaillon, Olivier Genetics https://doi.org/10.1534/genetics.117.300144	journal	August 2017
Biofilms as complex fluids Wilking, James N.; Angelini, Thomas E.; Seminara, Agnese MRS Bulletin, Vol. 36, Issue 5 https://doi.org/10.1557/mrs.2011.71	journal	May 2011
Fungal biofilms. Fanning, Saranna; Mitchell, Aaron Carnegie Mellon University https://doi.org/10.1184/r1/6099122	text	January 2012
Spatial structure, cooperation and competition in biofilms Nadell, Carey D.; Drescher, Knut; Foster, Kevin R. Nature Publishing Group https://doi.org/10.5451/unibas-ep83566	text	January 2016
Accumulation of Deleterious Mutations During Bacterial Range Expansions Bosshard, Lars; Dupanloup, Isabelle; Tenaillon, Olivier Genetics Society of America https://doi.org/10.7892/boris.118844	text	January 2017
On the accumulation of deleterious mutations during range expansions Duperret, Isabelle; Peischl, Stephan; Kirkpatrick, Mark Wiley-Blackwell https://doi.org/10.7892/boris.45484	text	January 2013
Life at the front of an expanding population Hallatschek, Oskar; Nelson, David R. arXiv https://doi.org/10.48550/arxiv.0810.0053	preprint	January 2008
A Quantitative Test of Population Genetics Using Spatio-Genetic Patterns in Bacterial Colonies Korolev, Kirill S.; Xavier, Joao B.; Nelson, David R. arXiv https://doi.org/10.48550/arxiv.1110.5376	text	January 2011
Scaling of Traction Forces with Size of Cohesive Cell Colonies Mertz, Aaron F.; Banerjee, Shiladitya; Che, Yonglu arXiv https://doi.org/10.48550/arxiv.1112.5804	text	January 2011
Selective sweeps in growing microbial colonies Korolev, Kirill S.; Müller, Melanie J. I.; Karahan, Nilay arXiv https://doi.org/10.48550/arxiv.1204.4896	text	January 2012
Radial Domany-Kinzel Models with Mutation and Selection Lavrentovich, Maxim O.; Korolev, Kirill S.; Nelson, David R. arXiv https://doi.org/10.48550/arxiv.1209.4103	text	January 2012
Mechanically driven growth of quasi-two dimensional microbial colonies Farrell, F. D. C.; Hallatschek, O.; Marenduzzo, D. arXiv https://doi.org/10.48550/arxiv.1303.6101	text	January 2013
On the accumulation of deleterious mutations during range expansions Peischl, Stephan; Dupanloup, Isabelle; Kirkpatrick, Mark arXiv https://doi.org/10.48550/arxiv.1306.1652	preprint	January 2013
Epithelial Organization: May the Force Be with You Fernandez-Gonzalez, Rodrigo; Zallen, Jennifer A. Current Biology, Vol. 18, Issue 4 https://doi.org/10.1016/j.cub.2007.12.030	journal	February 2008
Elastic Instability in Growing Yeast Colonies Nguyen, Baochi; Upadhyaya, Arpita; van Oudenaarden, Alexander Biophysical Journal, Vol. 86, Issue 5 https://doi.org/10.1016/s0006-3495(04)74327-1	journal	May 2004
Studies of bacterial branching growth using reaction–diffusion models for colonial development Golding, Ido; Kozlovsky, Yonathan; Cohen, Inon Physica A: Statistical Mechanics and its Applications, Vol. 260, Issue 3-4 https://doi.org/10.1016/s0378-4371(98)00345-8	journal	November 1998
Dynamic Scaling of Growing Interfaces Kardar, Mehran; Parisi, Giorgio; Zhang, Yi-Cheng Physical Review Letters, Vol. 56, Issue 9 https://doi.org/10.1103/physrevlett.56.889	journal	March 1986
Genetic demixing and evolution in linear stepping stone models Korolev, K. S.; Avlund, Mikkel; Hallatschek, Oskar Reviews of Modern Physics, Vol. 82, Issue 2 https://doi.org/10.1103/revmodphys.82.1691	journal	May 2010
Surfing downhill: when should population range expansion be characterized by reductions in fitness? Flaxman, Samuel M. Molecular Ecology, Vol. 22, Issue 24 https://doi.org/10.1111/mec.12564	journal	December 2013
Visualizing evolution as it happens McNally, Luke; Brown, Sam P. Science, Vol. 353, Issue 6304 https://doi.org/10.1126/science.aah5641	journal	September 2016
Finger Formation in Biofilm Layers Klapper, I.; Dockery, J. SIAM Journal on Applied Mathematics, Vol. 62, Issue 3 https://doi.org/10.1137/s0036139900371709	journal	January 2002
Clonal interference and Muller's ratchet in spatial habitats Otwinowski, Jakub; Krug, Joachim arXiv https://doi.org/10.48550/arxiv.1302.4326	text	January 2013
Spatial population expansion promotes the evolution of cooperation in an experimental Prisoner's Dilemma Van Dyken, J. David; Muller, Melanie J. I.; Mack, Keenan M. L. arXiv https://doi.org/10.48550/arxiv.1311.2646	text	January 2013
Mechanical interactions in bacterial colonies and the surfing probability of beneficial mutations Farrell, Fred F.; Gralka, Matti; Hallatschek, Oskar arXiv https://doi.org/10.48550/arxiv.1701.03337	preprint	January 2017

Cited By (3)

Environmental heterogeneity can tip the population genetics of range expansions Gralka, Matti; Hallatschek, Oskar eLife, Vol. 8 https://doi.org/10.7554/elife.44359	journal	April 2019
Nucleation of antagonistic organisms and cellular competitions on curved, inflating substrates Lavrentovich, Maxim O.; Nelson, David R. Physical Review E, Vol. 100, Issue 4 https://doi.org/10.1103/physreve.100.042406	journal	October 2019
Physical interactions reduce the power of natural selection in growing yeast colonies Giometto, Andrea; Nelson, David R.; Murray, Andrew W. Proceedings of the National Academy of Sciences, Vol. 115, Issue 45 https://doi.org/10.1073/pnas.1809587115	journal	October 2018

Similar Records

Measuring Cellular-scale Nutrient Distribution in Algal Biofilms with Synchrotron Confocal Infrared Microspectroscopy

Journal Article · Sat Dec 31 00:00:00 EST 2011 · Spectroscopy · OSTI ID:1506392

Murdock, J; Dodds, W; Reffner, J; +1 more

Nonequilibrium physics in biology

Journal Article · Fri Dec 20 00:00:00 EST 2019 · Reviews of Modern Physics · OSTI ID:1506392

Fang, Xiaona; Kruse, Karsten; Lu, Ting; +1 more

Pore-scale hydrodynamics influence the spatial evolution of bacterial biofilms in a microfluidic porous network

Journal Article · Thu Jun 27 00:00:00 EDT 2019 · PLoS ONE · OSTI ID:1506392

Aufrecht, Jayde A.; Fowlkes, Jason Davidson; Webb, Amber N.; +3 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Title: Collective motion conceals fitness differences in crowded cellular populations

Citation Formats

References (88)

Cited By (3)

Similar Records

Related Subjects