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Crystal structure of deglycosylated human IgG4-Fc
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The High-Affinity IgG Receptor, FcγRI, Plays a Central Role in Antibody Therapy of Experimental Melanoma
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IgG2 Fc structure and the dynamic features of the IgG CH2–CH3 interface
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High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR
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Quantitative in vivo comparisons of the Fcγ receptor-dependent agonist activities of different fucosylation variants of an immunoglobulin G antibody
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FcRn: the neonatal Fc receptor comes of age
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A single amino acid substitution abolishes the heterogeneity of chimeric mouse/human (IgG4) antibody
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A broad range of Fab stabilities within a host of therapeutic IgGs
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Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose
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In Vitro Characterization of Five Humanized OKT3 Effector Function Variant Antibodies
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Binding and Functional Comparisons of Two Types of Tumor Necrosis Factor Antagonists
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Intravenous immunoglobulins induce CD32-mediated platelet aggregation in vitro
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Structural Determinants of Unique Properties of Human IgG4-Fc
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Fc Optimization of Therapeutic Antibodies Enhances Their Ability to Kill Tumor Cells In vitro and Controls Tumor Expansion In vivo via Low-Affinity Activating Fc Receptors
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Fcγ receptors as regulators of immune responses
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Overview of the CCP 4 suite and current developments
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Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131
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Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions
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Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI
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Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective
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A Non-Activating “Humanized” Anti-Cd3 Monoclonal Antibody Retains Immunosuppressive Properties in vivo
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Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms
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Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters
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Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function
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Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
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Engineered antibody Fc variants with enhanced effector function
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An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations
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Humanized FcRn mouse models for evaluating pharmacokinetics of human IgG antibodies
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Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses
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The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of γ-globulin in humans
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Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors
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Structural characterization of a human Fc fragment engineered for lack of effector functions
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Humanized porcine VCAM-specific monoclonal antibodies with chimeric IgG2/G4 constant regions block human leukocyte binding to porcine endothelial cells
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HuM291, A HUMANIZED ANTI-CD3 ANTIBODY, IS IMMUNOSUPPRESSIVE TO T CELLS WHILE EXHIBITING REDUCED MITOGENICITY IN VITRO1
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Evaluation of an immunoassay for human-specific quantitation of therapeutic antibodies in serum samples from non-human primates
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Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice
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