Applications and challenges of forensic proteomics

Merkley, Eric D.; Wunschel, David S.; Wahl, Karen L.; Jarman, Kristin H.

doi:10.1016/j.forsciint.2019.01.022

Applications and challenges of forensic proteomics

Journal Article · Mon Apr 01 00:00:00 EDT 2019 · Forensic Science International

DOI:https://doi.org/10.1016/j.forsciint.2019.01.022· OSTI ID:1504445

; Wunschel, David S.; Wahl, Karen L.; Jarman, Kristin H.

Mass spectrometry-based proteomics has been a useful tool for addressing numerous questions in basic biology research for many years. This success, combined with the maturity of mass spectrometric instrumentation, the ever-increasing availability of protein sequence databases derived from genome sequencing, and the growing sophistication of data analysis methods, places proteomics in a position to have an important role in biological forensics. Because proteins contain information about genotype (sequence) and phenotype (expression levels), proteomics methods can both identify biological samples and characterize the conditions that produced them. In addition to serving as a valuable orthogonal method to genomic analyses, proteomics can be used in cases where nucleic acids are absent, degraded, or uninformative. Mass spectrometry provides both broad applicability and exquisite specificity, often without customized detection reagents like primers or antibodies. This review briefly introduces proteomics methods, and surveys a variety of forensic applications (including criminal justice, historical, archaeological, and national security areas). Finally, challenges and crucial areas for further research are addressed.

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1504445

Report Number(s):: PNNL-SA-139574

Journal Information:: Forensic Science International, Journal Name: Forensic Science International Journal Issue: C Vol. 297; ISSN 0379-0738

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

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From the Mouse to the Mass Spectrometer: Detection and Differentiation of the Endoproteinase Activities of Botulinum Neurotoxins A−G by Mass Spectrometry Boyer, Anne E.; Moura, Hercules; Woolfitt, Adrian R. Analytical Chemistry, Vol. 77, Issue 13 https://doi.org/10.1021/ac050485f	journal	July 2005
Spectral Library Generating Function for Assessing Spectrum-Spectrum Match Significance Wang, Mingxun; Bandeira, Nuno Journal of Proteome Research, Vol. 12, Issue 9 https://doi.org/10.1021/pr400230p	journal	July 2013
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Species Identification of Archaeological Skin Objects from Danish Bogs: Comparison between Mass Spectrometry-Based Peptide Sequencing and Microscopy-Based Methods Brandt, Luise Ørsted; Schmidt, Anne Lisbeth; Mannering, Ulla PLoS ONE, Vol. 9, Issue 9 https://doi.org/10.1371/journal.pone.0106875	journal	September 2014
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GC/MS and proteomics to unravel the painting history of the lost Giant Buddhas of Bāmiyān (Afghanistan) Lluveras-Tenorio, Anna; Vinciguerra, Roberto; Galano, Eugenio PLOS ONE, Vol. 12, Issue 4 https://doi.org/10.1371/journal.pone.0172990	journal	April 2017
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Top-down mass spectrometric immunoassay for human insulin and its therapeutic analogs Nedelkov, Dobrin; Niederkofler, Eric E.; Oran, Paul E. Journal of Proteomics, Vol. 175 https://doi.org/10.1016/j.jprot.2017.08.001	journal	March 2018
Understanding the improved sensitivity of spectral library searching over sequence database searching in proteomics data analysis Zhang, Xin; Li, Yunzi; Shao, Wenguang PROTEOMICS, Vol. 11, Issue 6 https://doi.org/10.1002/pmic.201000492	journal	February 2011
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Uniqueness in the forensic identification sciences—Fact or fiction? Page, Mark; Taylor, Jane; Blenkin, Matt Forensic Science International, Vol. 206, Issue 1-3 https://doi.org/10.1016/j.forsciint.2010.08.004	journal	March 2011
Mass spectrometry and illicit drug testing: analytical challenges of the anti-doping laboratories Botrè, Francesco Expert Review of Proteomics, Vol. 5, Issue 4 https://doi.org/10.1586/14789450.5.4.535	journal	August 2008
Analysis of active ricin and castor bean proteins in a ricin preparation, castor bean extract, and surface swabs from a public health investigation Schieltz, David M.; McGrath, Sara C.; McWilliams, Lisa G. Forensic Science International, Vol. 209, Issue 1-3 https://doi.org/10.1016/j.forsciint.2010.12.013	journal	June 2011
Ricin-like proteins from the castor plant do not influence liquid chromatography-mass spectrometry detection of ricin in forensically relevant samples Merkley, Eric D.; Jenson, Sarah C.; Arce, Jennifer S. Toxicon, Vol. 140 https://doi.org/10.1016/j.toxicon.2017.10.004	journal	December 2017

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