High Resolution Radionuclide Imaging Using Focusing Gamma-Ray Optics
Significant effort is being devoted to the development of noninvasive imaging systems that allow in vivo assessment of biological and biomolecular interactions in mice and other small animals. Although single-photon emission tomography (SPECT) and positron emission tomography (PET) are well-matched to the study of physiological function in small animals, the spatial resolutions of 1-2 mm currently achievable with these techniques limits the types of research possible. For this reason, we are developing a small animal radionuclide imaging system using grazing incidence optics to focus the low-energy gamma-rays emitted by {sup 125}I, {sup 95m}Tc, {sup 96}Tc, and {sup 99m}Tc. We compare this approach to the more traditional use of absorptive collimation.
- Research Organization:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 15013826
- Report Number(s):
- UCRL-CONF-202611; TRN: US200803%%853
- Resource Relation:
- Conference: Presented at: Workshop on Small Animal SPECT (Single Photon Emission Computed Tomography),, Tucson, AZ, United States, Jan 14 - Jan 16, 2004
- Country of Publication:
- United States
- Language:
- English
Towards in vivo nuclear microscopy: iodine-125 imaging in mice using micro-pinholes
|
journal | April 2002 |
First Images from HERO, a Hard X‐Ray Focusing Telescope
|
journal | March 2002 |
Performance evaluation of a pinhole SPECT system for myocardial perfusion imaging of mice
|
journal | November 2002 |
Development of thermally formed glass optics for astronomical hard X-ray telescopes
|
journal | January 2000 |
Small-animal radionuclide imaging with focusing gamma-ray optics
|
conference | January 2004 |
Similar Records
Pinhole SPECT: An approach to in vivo high resolution SPECT imaging in small laboratory animals
Rodent brain imaging with SPECT/CT