Trends in mass spectrometry instrumentation for proteomics
- BATTELLE (PACIFIC NW LAB)
Mass spectrometry has become a primary tool for proteomics due to its capabilities for rapid and sensitive protein identification and quantitation. It is now possible to identify thousands of proteins from microgram sample quantities in a single day and to quantify relative protein abundances. However, the needs for increased capabilities for proteome measurements are immense and are now driving both new strategies and instrument advances. These developments include those based on integration with multi-dimensional liquid separations and high accuracy mass measurements, and promise more than order of magnitude improvements in sensitivity, dynamic range, and throughput for proteomic analyses in the near future.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 15004601
- Report Number(s):
- PNNL-SA-36817; KP1102010; TRN: US201015%%754
- Journal Information:
- Trends in Biotechnology, 20(12):S3-S7, Vol. 20, Issue 12; ISSN 0167-7799
- Country of Publication:
- United States
- Language:
- English
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