Hybrid Nanogels for Sustainable Positive Thermosensitive Drug Release

Journal Article · Fri May 18 00:00:00 EDT 2001 · Journal of Controlled Release, 73):1-6

DOI:https://doi.org/10.1016/S0168-3659(01)00247-4· OSTI ID:15004350

Shin, Yongsoon ^[1]; Chang, Jeong H ^[2]; Liu, Jun ^[3]; Williford, Rick E ^[1]; Shin, Young-Kook ^[4]; Exarhos, Gregory J ^[1]

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1. BATTELLE (PACIFIC NW LAB)
2. ASSOC WESTERN UNIVERSITY
3. Lucent Bell Laboratories
4. Chungbuk National University

A hybrid nanogel is developed based on interpenetrating networks of thermosensitive PNIPAAm gels and tailored nanoporous silica. Sustainable positive thermo-responsive drug release profile is obtained. When the temperature rises, the polymer gel shrinks, squeezing the drug into the porous channels, and at the same time, opening the pore to the outside media. The drug slowly diffuses out of the porous channels. The overall release rate can be adjusted by changing the composition of the nanogel.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 15004350
• Report Number(s): PNNL-SA-34063; KC0201050
• Journal Information: Journal of Controlled Release, 73):1-6, Journal Name: Journal of Controlled Release, 73):1-6 Journal Issue: 1 Vol. 73; ISSN 0168-3659
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
77 NANOSCIENCE AND NANOTECHNOLOGY
DRUGS
GELS
NANOSTRUCTURES
POROUS MATERIALS
TEMPERATURE DEPENDENCE
THERAPY
controlled release
gels
hybrid
nanostructures
positive release