Solution Structure of Vibrio Cholerae Protein VC0424: A Variation of the Ferredoxin-like Fold
The structure of Vibrio cholerae protein VC0424 was determined by NMR spectroscopy. VC0424 belongs to a conserved family of bacterial proteins of unknown function (COG 3076) and previously unknown function. The structure has an a-b sandwich architecture consisting of two layers: a four stranded antiparallel b-sheet and three side-by-side a-helices. The secondary structure elements have the order ababbab along the sequence. This fold is the same as the ferredoxin-like fold, except with an additional long N-terminal helix, making it a variation on this common motif. A cluster of conserved surface residues on the b-sheet side of the protein forms a pocket that may be important for the biological function of this conserved family of proteins.
- Research Organization:
- Pacific Northwest National Lab., Richland, WA (US), Environmental Molecular Sciences Lab. (US)
- Sponsoring Organization:
- US Department of Energy (US)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 15004148
- Report Number(s):
- PNWD-SA-5995; 2327
- Journal Information:
- Protein Science, Journal Name: Protein Science Journal Issue: 7 Vol. 12
- Country of Publication:
- United States
- Language:
- English
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