Hemochromatosis heterozygotes may constitute a radiation-sensitive subpopulation.
Journal Article
·
· Radiation Research
OSTI ID:15001385
- GEORGE A GRANT INC
- BATTELLE (PACIFIC NW LAB)
A primary mechanism of radiation-induced DNA damage is by generation of free radicals. Chronically increased oxidative stress from elevated body iron may increase radiation sensitivity by decreasing cellular oxygen radical scavenging capability. Hemochromatosis heterozygotes have elevated body iron. Low-level radiation sensitization by iron may be particularly pertinent for risk of breast cancer. Since ten percent of the population appears to be heterozygous for the hemochromatosis gene, a radiosensitizing effect would have pervasive implications.
- Research Organization:
- Pacific Northwest National Lab., Richland, WA (US)
- Sponsoring Organization:
- US Department of Energy (US)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 15001385
- Report Number(s):
- PNNL-SA-33953; EW4090100; TRN: US200404%%100
- Journal Information:
- Radiation Research, Vol. 153, Issue 6; Other Information: PBD: 1 Dec 1999
- Country of Publication:
- United States
- Language:
- English
Similar Records
Sensitivity to Radiation-Induced Cancer in Hemochromatosis
Impact on radiogenic cancer risk of persons exhibiting abnormal sensitivity to ionizing radiation
The sensitivity of human mesenchymal stem cells to ionizing radiation
Technical Report
·
Thu Jun 01 00:00:00 EDT 2000
·
OSTI ID:15001385
Impact on radiogenic cancer risk of persons exhibiting abnormal sensitivity to ionizing radiation
Journal Article
·
Mon Aug 01 00:00:00 EDT 1988
· Health Phys.; (United States)
·
OSTI ID:15001385
The sensitivity of human mesenchymal stem cells to ionizing radiation
Journal Article
·
Fri Sep 01 00:00:00 EDT 2006
· International Journal of Radiation Oncology, Biology and Physics
·
OSTI ID:15001385
+6 more