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Title: Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors

Authors:
 [1];  [1];  [2];  [3];  [2];  [4];  [5];  [4];  [3];  [4];  [6];  [1]; ORCiD logo [7]; ORCiD logo [8]
  1. Cayman Chemical Company, 1180 East Ellsworth, Ann Arbor, Michigan 48108, United States
  2. California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States
  3. Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States
  4. Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, New York 10065, United States
  5. Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02215, United States
  6. Department of Radiation Oncology, Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York 10016, United States
  7. California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
  8. Department of Molecular and Integrative Physiology, Department of Internal Medicine, Division of Gastroenterology, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NIHOTHER
OSTI Identifier:
1499730
Resource Type:
Journal Article
Journal Name:
Biochemistry
Additional Journal Information:
Journal Volume: 57; Journal Issue: 47; Journal ID: ISSN 0006-2960
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Holt, Melissa C., Assar, Zahra, Beheshti Zavareh, Reza, Lin, Lin, Anglin, Justin, Mashadova, Oksana, Haldar, Daniel, Mullarky, Edouard, Kremer, Daniel M., Cantley, Lewis C., Kimmelman, Alec C., Stein, Adam J., Lairson, Luke L., and Lyssiotis, Costas A. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. United States: N. p., 2018. Web. doi:10.1021/acs.biochem.8b00914.
Holt, Melissa C., Assar, Zahra, Beheshti Zavareh, Reza, Lin, Lin, Anglin, Justin, Mashadova, Oksana, Haldar, Daniel, Mullarky, Edouard, Kremer, Daniel M., Cantley, Lewis C., Kimmelman, Alec C., Stein, Adam J., Lairson, Luke L., & Lyssiotis, Costas A. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. United States. doi:10.1021/acs.biochem.8b00914.
Holt, Melissa C., Assar, Zahra, Beheshti Zavareh, Reza, Lin, Lin, Anglin, Justin, Mashadova, Oksana, Haldar, Daniel, Mullarky, Edouard, Kremer, Daniel M., Cantley, Lewis C., Kimmelman, Alec C., Stein, Adam J., Lairson, Luke L., and Lyssiotis, Costas A. Fri . "Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors". United States. doi:10.1021/acs.biochem.8b00914.
@article{osti_1499730,
title = {Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors},
author = {Holt, Melissa C. and Assar, Zahra and Beheshti Zavareh, Reza and Lin, Lin and Anglin, Justin and Mashadova, Oksana and Haldar, Daniel and Mullarky, Edouard and Kremer, Daniel M. and Cantley, Lewis C. and Kimmelman, Alec C. and Stein, Adam J. and Lairson, Luke L. and Lyssiotis, Costas A.},
abstractNote = {},
doi = {10.1021/acs.biochem.8b00914},
journal = {Biochemistry},
issn = {0006-2960},
number = 47,
volume = 57,
place = {United States},
year = {2018},
month = {10}
}