Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Structural basis for potent antibody-mediated neutralization of human cytomegalovirus

Journal Article · · Science Immunology
Abstract not provided
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
INDUSTRY
OSTI ID:
1498422
Journal Information:
Science Immunology, Journal Name: Science Immunology Journal Issue: 12 Vol. 2; ISSN 2470-9468
Country of Publication:
United States
Language:
ENGLISH

References (39)

Two novel spliced genes in human cytomegalovirus journal May 2003
HCMV gH/gL/UL128-131 interferes with virus entry into epithelial cells: Evidence for cell type-specific receptors journal September 2008
Human Cytomegalovirus UL131-128 Genes Are Indispensable for Virus Growth in Endothelial Cells and Virus Transfer to Leukocytes journal August 2004
Vaccine Development to Prevent Cytomegalovirus Disease: Report from the National Vaccine Advisory Committee journal July 2004
Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines journal January 2013
Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex journal November 2009
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Human Cytomegalovirus Persists in Its Host and Attacks and Avoids Elimination by the Immune System journal January 2006
Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies journal December 2014
Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL journal July 2010
Manifestations of Human Cytomegalovirus Infection: Proposed Mechanisms of Acute and Chronic Disease book January 2008
Vaccine-Derived Neutralizing Antibodies to the Human Cytomegalovirus gH/gL Pentamer Potently Block Primary Cytotrophoblast Infection journal September 2015
Phaser crystallographic software journal July 2007
GlyProt: in silico glycosylation of proteins journal July 2005
Dendritic-cell infection by human cytomegalovirus is restricted to strains carrying functional UL131-128 genes and mediates efficient viral antigen presentation to CD8+ T cells journal February 2005
Congenital Cytomegalovirus Infection: Clinical Outcome journal November 2013
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus journal October 2013
Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex journal December 2010
Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies journal October 2015
Cascade of Events Governing Cell-Cell Fusion Induced by Herpes Simplex Virus Glycoproteins gD, gH/gL, and gB journal September 2010
A replication-defective human cytomegalovirus vaccine for prevention of congenital infection journal October 2016
A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL journal April 2015
Human cytomegalovirus gH/gL/UL128/UL130/UL131A complex elicits potently neutralizing antibodies in mice journal June 2014
A Vaccine Based on the Rhesus Cytomegalovirus UL128 Complex Induces Broadly Neutralizing Antibodies in Rhesus Macaques journal November 2012
Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody journal December 2010
Fetal Human Cytomegalovirus Transmission Correlates with Delayed Maternal Antibodies to gH/gL/pUL128-130-131 Complex during Primary Infection journal March 2013
Expression of the human cytomegalovirus pentamer complex for vaccine use in a CHO system: CHO Expression of HCMV Pentamer journal July 2015
Coot model-building tools for molecular graphics journal November 2004
Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism journal November 2005
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
XDS journal January 2010
Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry journal February 2013
Antibodies Against Neutralization Epitopes of Human Cytomegalovirus gH/gL/pUL128-130-131 Complex and Virus Spreading May Correlate with Virus Control In Vivo journal July 2012
The history of vaccination against cytomegalovirus journal March 2015
Cytomegalovirus infection in solid organ transplant recipients: New challenges and their implications for preventive strategies journal April 2006
The Large Groove Found in the gH/gL Structure Is an Important Functional Domain for Epstein-Barr Virus Fusion journal January 2013
Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus journal December 2012
Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes journal January 2015
Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER journal March 2012

Similar Records

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
Journal Article · Tue Feb 07 23:00:00 EST 2012 · Science · OSTI ID:1034537

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies
Journal Article · Tue Nov 03 23:00:00 EST 2020 · Cell · OSTI ID:1701760

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies
Journal Article · Mon Oct 05 00:00:00 EDT 2020 · Cell · OSTI ID:1671111

Related Subjects