Genetically Engineered Elastomeric Polymer Network through Protein Zipper Assembly

Fazelinia, Hossein; Balog, Eva Rose M.; Desireddy, Anil; Chakraborty, Saumen; Sheehan, Chris J.; Strauss, Charlie E. M.; Martinez, Jennifer S.

doi:10.1002/slct.201700456

Genetically Engineered Elastomeric Polymer Network through Protein Zipper Assembly

Journal Article · Tue Jul 18 00:00:00 EDT 2017 · Chemistry Select

DOI:https://doi.org/10.1002/slct.201700456· OSTI ID:1498046

Fazelinia, Hossein ^[1]; Balog, Eva Rose M. ^[1]; Desireddy, Anil ^[1]; Chakraborty, Saumen ^[1]; Sheehan, Chris J. ^[1]; ^[1]; ^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

The rich palette of chemical and functional diversity found within peptides has driven the recent interest in bottom–up assembly of soft polypeptide–based materials. Herein, we describe the creation of a novel helix–elastin like polymer or HELP. HELP marries the specificity of coiled–coil interactions with the elasticity and stimuli–responsive behavior of elastin, a class of polymers with extraordinary elasticity. We used Rosetta to computationally design highly specific protein helical zippers to connect short elastin segments. As a result, the programmed pairing between the helical blocks of two individual chains produced a genetically encoded material that, when deposited on a substrate, formed a flexible and porous 2D planar network with controllable porosity that responds dynamically upon application of stimuli.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1498046

Report Number(s):: LA-UR--16-20868

Journal Information:: Chemistry Select, Journal Name: Chemistry Select Journal Issue: 18 Vol. 2; ISSN 2365-6549

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Related Subjects

36 MATERIALS SCIENCE
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Elastin like polymer
Helical zipper
Material Science
Protein design
Self-assembly
Stimuli responsive polymer

Genetically Engineered Elastomeric Polymer Network through Protein Zipper Assembly

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