Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In&nbsp;Vivo

Borkin, Dmitry; He, Shihan; Miao, Hongzhi; Kempinska, Katarzyna; Pollock, Jonathan; Chase, Jennifer; Purohit, Trupta; Malik, Bhavna; Zhao, Ting; Wang, Jingya; Wen, Bo; Zong, Hongliang; Jones, Morgan; Danet-Desnoyers, Gwenn; Guzman, Monica L.; Talpaz, Moshe; Bixby, Dale L.; Sun, Duxin; Hess, Jay L.; Muntean, Andrew G.; Maillard, Ivan; Cierpicki, Tomasz; Grembecka, Jolanta

doi:10.1016/j.ccell.2015.02.016

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

Journal Article · Wed Apr 01 04:00:00 EDT 2015 · Cancer Cell

DOI:https://doi.org/10.1016/j.ccell.2015.02.016· OSTI ID:1497151

Borkin, Dmitry; He, Shihan; Miao, Hongzhi; Kempinska, Katarzyna; Pollock, Jonathan; Chase, Jennifer; Purohit, Trupta; Malik, Bhavna; Zhao, Ting; Wang, Jingya; Wen, Bo; Zong, Hongliang; Jones, Morgan; Danet-Desnoyers, Gwenn; Guzman, Monica L.; Talpaz, Moshe; Bixby, Dale L.; Sun, Duxin; Hess, Jay L.; Muntean, Andrew G. more »

Abstract not provided

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: NIH

OSTI ID:: 1497151

Journal Information:: Cancer Cell, Journal Name: Cancer Cell Journal Issue: 4 Vol. 27; ISSN 1535-6108

Publisher:: Elsevier

Country of Publication:: United States

Language:: ENGLISH

References (36)

Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation Caslini, C.; Yang, Z.; El-Osta, M. Cancer Research, Vol. 67, Issue 15 https://doi.org/10.1158/0008-5472.can-06-2369	journal	August 2007
The role of MLL in hematopoiesis and leukemia Ernst, Patricia; Wang, Jing; Korsmeyer, Stanley J. Current Opinion in Hematology, Vol. 9, Issue 4 https://doi.org/10.1097/00062752-200207000-00004	journal	January 2002
Outcome of risk-based therapy for infant acute lymphoblastic leukemia with or without an MLL gene rearrangement, with emphasis on late effects: a final report of two consecutive studies, MLL96 and MLL98, of the Japan Infant Leukemia Study Group Tomizawa, D.; Koh, K.; Sato, T. Leukemia, Vol. 21, Issue 11 https://doi.org/10.1038/sj.leu.2404903	journal	August 2007
Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells Gal, H.; Amariglio, N.; Trakhtenbrot, L. Leukemia, Vol. 20, Issue 12 https://doi.org/10.1038/sj.leu.2404401	journal	October 2006
Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation Caslini, C.; Yang, Z.; El-Osta, M. Cancer Research, Vol. 67, Issue 15 https://doi.org/10.1158/0008-5472.CAN-06-2369	journal	August 2007
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells Li, Bin E.; Gan, Tao; Meyerson, Matthew Blood, Vol. 122, Issue 12 https://doi.org/10.1182/blood-2013-03-486647	journal	September 2013
MLL rearrangements in haematological malignancies: lessons from clinical and biological studies DiMartino, Jorge F.; Cleary, Michael L. British Journal of Haematology, Vol. 106, Issue 3 https://doi.org/10.1046/j.1365-2141.1999.01439.x	journal	September 1999
An MLL-dependent network sustains hematopoiesis Artinger, E. L.; Mishra, B. P.; Zaffuto, K. M. Proceedings of the National Academy of Sciences, Vol. 110, Issue 29 https://doi.org/10.1073/pnas.1301278110	journal	June 2013
Mll Has a Critical Role in Fetal and Adult Hematopoietic Stem Cell Self-Renewal McMahon, Kathryn A.; Hiew, Samantha Y. -L.; Hadjur, Suzana Cell Stem Cell, Vol. 1, Issue 3 https://doi.org/10.1016/j.stem.2007.07.002	journal	September 2007
The Role of Menin in Hematopoiesis Maillard, Ivan; Hess, Jay L. SuperMEN1, p. 51-57 https://doi.org/10.1007/978-1-4419-1664-8_5	book	January 2009
DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia Figueroa, Maria E.; Lugthart, Sanne; Li, Yushan Cancer Cell, Vol. 17, Issue 1 https://doi.org/10.1016/j.ccr.2009.11.020	journal	January 2010
The evolving landscape in the therapy of acute myeloid leukemia Peloquin, Grace L.; Chen, Yi-Bin; Fathi, Amir T. Protein & Cell, Vol. 4, Issue 10 https://doi.org/10.1007/s13238-013-3057-2	journal	August 2013
The molecular biology of mixed lineage leukemia Slany, R. K. Haematologica, Vol. 94, Issue 7 https://doi.org/10.3324/haematol.2008.002436	journal	June 2009
When epigenetics kills: MLL fusion proteins in leukemia Slany, Robert K. Hematological Oncology, Vol. 23, Issue 1 https://doi.org/10.1002/hon.739	journal	March 2005
MLL translocations, histone modifications and leukaemia stem-cell development Krivtsov, Andrei V.; Armstrong, Scott A. Nature Reviews Cancer, Vol. 7, Issue 11 https://doi.org/10.1038/nrc2253	journal	November 2007
High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction He, Shihan; Senter, Timothy J.; Pollock, Jonathan Journal of Medicinal Chemistry, Vol. 57, Issue 4 https://doi.org/10.1021/jm401868d	journal	February 2014
MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L Bernt, Kathrin M.; Zhu, Nan; Sinha, Amit U. Cancer Cell, Vol. 20, Issue 1 https://doi.org/10.1016/j.ccr.2011.06.010	journal	July 2011
The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis Yokoyama, Akihiko; Somervaille, Tim C. P.; Smith, Kevin S. Cell, Vol. 123, Issue 2 https://doi.org/10.1016/j.cell.2005.09.025	journal	October 2005
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription Xu, B.; Li, S. -H.; Zheng, R. Proceedings of the National Academy of Sciences, Vol. 110, Issue 43 https://doi.org/10.1073/pnas.1312022110	journal	October 2013
Mechanisms of leukemogenesis by MLL fusion proteins: Review Marschalek, Rolf British Journal of Haematology, Vol. 152, Issue 2 https://doi.org/10.1111/j.1365-2141.2010.08459.x	journal	December 2010
Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells Luc, Sidinh; Orkin, Stuart H. Proceedings of the National Academy of Sciences, Vol. 110, Issue 29 https://doi.org/10.1073/pnas.1310349110	journal	July 2013
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia Zuber, Johannes; Shi, Junwei; Wang, Eric Nature, Vol. 478, Issue 7370 https://doi.org/10.1038/nature10334	journal	August 2011
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Somervaille, Tim C. P.; Cleary, Michael L. Cancer Cell, Vol. 10, Issue 4 https://doi.org/10.1016/j.ccr.2006.08.020	journal	October 2006
Molecular Basis of the Mixed Lineage Leukemia-Menin Interaction: IMPLICATIONS FOR TARGETING MIXED LINEAGE LEUKEMIAS Grembecka, Jolanta; Belcher, Amalia M.; Hartley, Thomas Journal of Biological Chemistry, Vol. 285, Issue 52 https://doi.org/10.1074/jbc.M110.172783	journal	October 2010
Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes Yokoyama, Akihiko; Cleary, Michael L. Cancer Cell, Vol. 14, Issue 1 https://doi.org/10.1016/j.ccr.2008.05.003	journal	July 2008
Global Gene Expression Profile of Human Cord Blood-Derived CD133 ⁺ Cells Jaatinen, Taina; Hemmoranta, Heidi; Hautaniemi, Sampsa Stem Cells, Vol. 24, Issue 3 https://doi.org/10.1634/stemcells.2005-0185	journal	March 2006
MLL: a histone methyltransferase disrupted in leukemia Hess, Jay L. Trends in Molecular Medicine, Vol. 10, Issue 10 https://doi.org/10.1016/j.molmed.2004.08.005	journal	October 2004
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia Grembecka, Jolanta; He, Shihan; Shi, Aibin Nature Chemical Biology, Vol. 8, Issue 3 https://doi.org/10.1038/nchembio.773	journal	January 2012
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia Guenther, M. G.; Lawton, L. N.; Rozovskaia, T. Genes & Development, Vol. 22, Issue 24 https://doi.org/10.1101/gad.1741408	journal	December 2008
Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9 Krivtsov, Andrei V.; Twomey, David; Feng, Zhaohui Nature, Vol. 442, Issue 7104 https://doi.org/10.1038/nature04980	journal	July 2006
Menin regulates the function of hematopoietic stem cells and lymphoid progenitors Maillard, Ivan; Chen, Ya-Xiong; Friedman, Ann Blood, Vol. 113, Issue 8 https://doi.org/10.1182/blood-2008-01-135012	journal	February 2009
Cancer epigenetics reaches mainstream oncology Rodríguez-Paredes, Manuel; Esteller, Manel Nature Medicine, Vol. 17, Issue 3 https://doi.org/10.1038/nm.2305	journal	March 2011
Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia Shi, Aibin; Murai, Marcelo J.; He, Shihan Blood, Vol. 120, Issue 23 https://doi.org/10.1182/blood-2012-05-429274	journal	November 2012
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells Knutson, Sarah K.; Wigle, Tim J.; Warholic, Natalie M. Nature Chemical Biology, Vol. 8, Issue 11 https://doi.org/10.1038/nchembio.1084	journal	September 2012
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia Dawson, Mark A.; Prinjha, Rab K.; Dittmann, Antje Nature, Vol. 478, Issue 7370 https://doi.org/10.1038/nature10509	journal	October 2011
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor Daigle, Scott R.; Olhava, Edward J.; Therkelsen, Carly A. Cancer Cell, Vol. 20, Issue 1 https://doi.org/10.1016/j.ccr.2011.06.009	journal	July 2011

Cited By (53)

Menin regulates the serine biosynthetic pathway in Ewing sarcoma: Menin-dependent regulation of serine biosynthesis Svoboda, Laurie K.; Teh, Selina Shiqing K.; Sud, Sudha The Journal of Pathology, Vol. 245, Issue 3 https://doi.org/10.1002/path.5085	journal	May 2018
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4. Tzelepis, Konstantinos; De Braekeleer, Etienne; Aspris, Demetrios Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.35021	text	January 2018
New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise Bohl, Stephan R.; Bullinger, Lars; Rücker, Frank G. International Journal of Molecular Sciences, Vol. 20, Issue 8 https://doi.org/10.3390/ijms20081983	journal	April 2019
Targeting Transcription Factors for Cancer Treatment Lambert, Mélanie; Jambon, Samy; Depauw, Sabine Molecules, Vol. 23, Issue 6 https://doi.org/10.3390/molecules23061479	journal	June 2018
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 Tzelepis, Konstantinos; De Braekeleer, Etienne; Aspris, Demetrios Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-07620-0	journal	December 2018
Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin Bochynska, Agnieszka; Lüscher-Firzlaff, Juliane; Lüscher, Bernhard RWTH Aachen University https://doi.org/10.18154/rwth-conv-236812	text	January 2018
Design of the First‐in‐Class, Highly Potent Irreversible Inhibitor Targeting the Menin‐MLL Protein–Protein Interaction Xu, Shilin; Aguilar, Angelo; Xu, Tianfeng Angewandte Chemie, Vol. 130, Issue 6 https://doi.org/10.1002/ange.201711828	journal	January 2018
Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation Cermakova, Katerina; Hodges, H. Molecules, Vol. 23, Issue 8 https://doi.org/10.3390/molecules23081958	journal	August 2018
Dasatinib and navitoclax act synergistically to target NUP98-NSD1+/FLT3-ITD+ acute myeloid leukemia Kivioja, Jarno L.; Thanasopoulou, Angeliki; Kumar, Ashwini Leukemia, Vol. 33, Issue 6 https://doi.org/10.1038/s41375-018-0327-2	journal	December 2018
Targeting chromatin complexes in fusion protein-driven malignancies Brien, Gerard L.; Stegmaier, Kimberly; Armstrong, Scott A. Nature Reviews Cancer, Vol. 19, Issue 5 https://doi.org/10.1038/s41568-019-0132-x	journal	April 2019
DNMT3A in Leukemia Brunetti, Lorenzo; Gundry, Michael C.; Goodell, Margaret A. Cold Spring Harbor Perspectives in Medicine, Vol. 7, Issue 2 https://doi.org/10.1101/cshperspect.a030320	journal	December 2016
Targeted Therapies for Pediatric AML: Gaps and Perspective Lonetti, Annalisa; Pession, Andrea; Masetti, Riccardo Frontiers in Pediatrics, Vol. 7 https://doi.org/10.3389/fped.2019.00463	journal	November 2019
Targeting human SET1/MLL family of proteins: SET1/MLL Family of Proteins Vedadi, Masoud; Blazer, Levi; Eram, Mohammad S. Protein Science, Vol. 26, Issue 4 https://doi.org/10.1002/pro.3129	journal	March 2017
Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia Brzezinka, Krzysztof; Nevedomskaya, Ekaterina; Lesche, Ralf Journal of Hematology & Oncology, Vol. 12, Issue 1 https://doi.org/10.1186/s13045-019-0749-y	journal	June 2019
Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia Sun, Younguk; Chen, Bo-Rui; Deshpande, Aniruddha Frontiers in Oncology, Vol. 8 https://doi.org/10.3389/fonc.2018.00041	journal	February 2018
The efficiency of murine MLL-ENL–driven leukemia initiation changes with age and peaks during neonatal development Okeyo-Owuor, Theresa; Li, Yanan; Patel, Riddhi M. Blood Advances, Vol. 3, Issue 15 https://doi.org/10.1182/bloodadvances.2019000554	journal	August 2019
Targeted therapy for fusion-driven high-risk acute leukemia Pikman, Yana; Stegmaier, Kimberly Blood, Vol. 132, Issue 12 https://doi.org/10.1182/blood-2018-04-784157	journal	September 2018
Establishment and characterization of a DOT1L inhibitor‐sensitive human acute monocytic leukemia cell line YBT‐5 with a novel KMT2A‐MLLT3 fusion Wang, Zhenhua; Shi, Yongjin; Liu, Huihui Hematological Oncology, Vol. 37, Issue 5 https://doi.org/10.1002/hon.2686	journal	November 2019
Inhibitors of Protein Methyltransferases and Demethylases Kaniskan, H. Ümit; Martini, Michael L.; Jin, Jian Chemical Reviews, Vol. 118, Issue 3 https://doi.org/10.1021/acs.chemrev.6b00801	journal	March 2017
High-dose, short-term glucocorticoids for the treatment of infertility resulting from premature ovarian failure Corenblum, Bernard; Rowe, Timothy; Taylor, Patrick J. Fertility and Sterility, Vol. 59, Issue 5 https://doi.org/10.1016/s0015-0282(16)55915-9	journal	May 1993
Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia Krivtsov, Andrei V.; Hoshii, Takayuki; Armstrong, Scott A. Cold Spring Harbor Perspectives in Medicine, Vol. 7, Issue 11 https://doi.org/10.1101/cshperspect.a026658	journal	February 2017
Epigenetic balance of gene expression by Polycomb and COMPASS families Piunti, Andrea; Shilatifard, Ali Science, Vol. 352, Issue 6290 https://doi.org/10.1126/science.aad9780	journal	June 2016
Molecular Approaches to Treating Pediatric Leukemias Kuhlen, Michaela; Klusmann, Jan-Henning; Hoell, Jessica I. Frontiers in Pediatrics, Vol. 7 https://doi.org/10.3389/fped.2019.00368	journal	September 2019
Epigenetic modifications of histones in cancer Zhao, Zibo; Shilatifard, Ali Genome Biology, Vol. 20, Issue 1 https://doi.org/10.1186/s13059-019-1870-5	journal	November 2019
Therapeutic targeting potential of chromatin-associated proteins in MLL-rearranged acute leukemia Xu, Xin; Schneider, Björn Cellular Oncology, Vol. 42, Issue 2 https://doi.org/10.1007/s13402-018-0414-4	journal	November 2018
Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours Jones, David T. W.; Banito, Ana; Grünewald, Thomas G. P. Nature Reviews Cancer, Vol. 19, Issue 8 https://doi.org/10.1038/s41568-019-0169-x	journal	July 2019
Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target Brzezinka, Krzysztof; Nevedomskaya, Ekaterina; Lesche, Ralf Cancers, Vol. 12, Issue 1 https://doi.org/10.3390/cancers12010201	journal	January 2020
Polycomb complexes in normal and malignant hematopoiesis Di Carlo, Valerio; Mocavini, Ivano; Di Croce, Luciano Journal of Cell Biology, Vol. 218, Issue 1 https://doi.org/10.1083/jcb.201808028	journal	October 2018
Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia Lu, Rui; Wang, Gang Greg Frontiers in Oncology, Vol. 7 https://doi.org/10.3389/fonc.2017.00241	journal	October 2017
Isolation of MLL1 Inhibitory RNA Aptamers Ul-Haq, Asad; Jin, Ming Li; Jeong, Kwang Won Biomolecules & Therapeutics, Vol. 27, Issue 2 https://doi.org/10.4062/biomolther.2018.157	journal	March 2019
How to effectively treat acute leukemia patients bearing MLL-rearrangements ? Steinhilber, Dieter; Marschalek, Rolf Biochemical Pharmacology, Vol. 147 https://doi.org/10.1016/j.bcp.2017.09.007	journal	January 2018
Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia Klossowski, Szymon; Miao, Hongzhi; Kempinska, Katarzyna Journal of Clinical Investigation, Vol. 130, Issue 2 https://doi.org/10.1172/jci129126	journal	December 2019
The molecular mechanics of mixed lineage leukemia Slany, R. K. Oncogene, Vol. 35, Issue 40 https://doi.org/10.1038/onc.2016.30	journal	February 2016
Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction Zhong, Hai-Jing; Lee, Bo Ra; Boyle, Joshua William Chemical Communications, Vol. 52, Issue 34 https://doi.org/10.1039/c6cc01079b	journal	January 2016
Deregulation of the HOXA9/MEIS1 axis in acute leukemia Collins, Cailin T.; Hess, Jay L. Current Opinion in Hematology, Vol. 23, Issue 4 https://doi.org/10.1097/moh.0000000000000245	journal	July 2016
The upstreams and downstreams of H3K79 methylation by DOT1L Vlaming, Hanneke; van Leeuwen, Fred Chromosoma, Vol. 125, Issue 4 https://doi.org/10.1007/s00412-015-0570-5	journal	January 2016
Epigenetics of hematopoiesis and hematological malignancies Hu, Deqing; Shilatifard, Ali Genes & Development, Vol. 30, Issue 18 https://doi.org/10.1101/gad.284109.116	journal	September 2016
PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer Spangle, Jennifer M.; Dreijerink, Koen M.; Groner, Anna C. Cell Reports, Vol. 15, Issue 12 https://doi.org/10.1016/j.celrep.2016.05.046	journal	June 2016
Using Structural Analysis In Silico to Assess the Impact of Missense Variants in MEN1 Caswell, Richard C.; Owens, Martina M.; Gunning, Adam C. Journal of the Endocrine Society, Vol. 3, Issue 12 https://doi.org/10.1210/js.2019-00260	journal	September 2019
Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL-Rearranged Acute Lymphoblastic Leukemia Kerstjens, Mark; Garrido Castro, Patricia; Pinhanços, Sandra S. Biomedicines, Vol. 9, Issue 7 https://doi.org/10.3390/biomedicines9070711	journal	June 2021
Protein methyltransferase inhibitors as precision cancer therapeutics: a decade of discovery Copeland, Robert A. Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 373, Issue 1748 https://doi.org/10.1098/rstb.2017.0080	journal	April 2018
Targeting transcription factors in cancer — from undruggable to reality Bushweller, John H. Nature Reviews Cancer, Vol. 19, Issue 11 https://doi.org/10.1038/s41568-019-0196-7	journal	September 2019
Pediatric Acute Myeloid Leukemia (AML): From Genes to Models Toward Targeted Therapeutic Intervention Mercher, Thomas; Schwaller, Juerg Frontiers in Pediatrics, Vol. 7 https://doi.org/10.3389/fped.2019.00401	journal	October 2019
Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin Bochyńska, Agnieszka; Lüscher-Firzlaff, Juliane; Lüscher, Bernhard Cells, Vol. 7, Issue 3 https://doi.org/10.3390/cells7030017	journal	March 2018
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy Lan, X.; Joerg, David; Cavalli, Fmg Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.12203	text	January 2017
Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair Ye, Jing; Zha, Jie; Shi, Yuanfei Clinical Epigenetics, Vol. 11, Issue 1 https://doi.org/10.1186/s13148-019-0723-0	journal	October 2019
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy Lan, Xiaoyang; Jörg, David J.; Cavalli, Florence M. G. Nature, Vol. 549, Issue 7671 https://doi.org/10.1038/nature23666	journal	August 2017
Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction Xu, Shilin; Aguilar, Angelo; Xu, Tianfeng Angewandte Chemie International Edition, Vol. 57, Issue 6 https://doi.org/10.1002/anie.201711828	journal	January 2018
Accurate Medicine: Indirect Targeting of NPM1-Mutated AML Hourigan, Christopher S.; Aplan, Peter D. Cancer Discovery, Vol. 6, Issue 10 https://doi.org/10.1158/2159-8290.cd-16-0917	journal	October 2016
Emerging Epigenetic Therapeutic Targets in Acute Myeloid Leukemia Wingelhofer, Bettina; Somervaille, Tim C. P. Frontiers in Oncology, Vol. 9 https://doi.org/10.3389/fonc.2019.00850	journal	September 2019
New and Emerging Targeted Therapies for Pediatric Acute Myeloid Leukemia (AML) Chen, Jing; Glasser, Chana Children, Vol. 7, Issue 2 https://doi.org/10.3390/children7020012	journal	February 2020
Direct and Indirect Targeting of HOXA9 Transcription Factor in Acute Myeloid Leukemia. No authors listed Cancers, Vol. 11, Issue 6 https://doi.org/10.3390/cancers11060837	journal	June 2019
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia Uckelmann, Hannah J.; Kim, Stephanie M.; Wong, Eric M. Science, Vol. 367, Issue 6477 https://doi.org/10.1126/science.aax5863	journal	January 2020

Similar Records

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

Journal Article · Tue Mar 31 20:00:00 EDT 2015 · Cancer Cell · OSTI ID:1247185

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

Journal Article · Thu Oct 02 00:00:00 EDT 2014 · Blood · OSTI ID:1094851

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

Citation Formats

References (36)

Cited By (53)

Similar Records

Related Subjects