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Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor

Journal Article · · Molecular Cell

Abstract not provided

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
NIHFOREIGN
OSTI ID:
1497150
Journal Information:
Molecular Cell, Journal Name: Molecular Cell Journal Issue: 6 Vol. 58; ISSN 1097-2765
Publisher:
Cell Press - Elsevier
Country of Publication:
United States
Language:
ENGLISH

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Turn Structures in CGRP C-Terminal Analogues Promote Stable Arrangements of Key Residue Side Chains journal July 2001
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G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection journal May 2013
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Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides journal October 2009
Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain journal February 2008
RAMP-ing up Class-B GPCR ECD Structural Coverage journal September 2010
Pramlintide in the Treatment of Diabetes Mellitus journal January 2008
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Identification of N-Terminal Receptor Activity-Modifying Protein Residues Important for Calcitonin Gene-Related Peptide, Adrenomedullin, and Amylin Receptor Function journal July 2008
Overview of the CCP 4 suite and current developments journal March 2011
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Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled Receptors journal May 2011
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Functional Calcitonin Gene-related Peptide Receptors Are Formed by the Asymmetric Assembly of a Calcitonin Receptor-like Receptor Homo-oligomer and a Monomer of Receptor Activity-modifying Protein-1 journal October 2007
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Cited By (26)

Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation text January 2017
Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development: Amylin structure-function journal May 2016
Crystal structures of MBP fusion proteins: Structures of MBP Fusion Proteins journal January 2016
The Impact of Adrenomedullin Thr22 on Selectivity within the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein System journal July 2018
Multiplexed analysis of the secretin-like GPCR-RAMP interactome journal September 2019
GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents journal December 2017
Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins journal April 2016
CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured journal February 2017
A Molecular Dynamics Study of Vasoactive Intestinal Peptide Receptor 1 and the Basis of Its Therapeutic Antagonism journal September 2019
Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS journal February 2016
Stachel -independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region journal September 2017
Multiplexed Analysis of the Secretin-like GPCR-RAMP Interactome journal April 2019
Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2) journal September 2015
Adrenomedullin disulfide bond mimetics uncover structural requirements for AM 1 receptor activation journal January 2019
Amylin: Pharmacology, Physiology, and Clinical Potential text January 2015
CGRP and its receptors journal February 2017
Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography journal May 2016
Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors. journal December 2016
Amylin journal May 2017
Molecular studies of CGRP and the CGRP family of peptides in the central nervous system journal March 2018
An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology journal May 2016
Amylin: Pharmacology, Physiology, and Clinical Potential journal June 2015
Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy journal April 2018
Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25: Pharmacology of the calcitonin/CGRP family journal November 2017
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor journal September 2018
Calcitonin Gene‐Related Peptide Modulators – The History and Renaissance of a New Migraine Drug Class journal April 2019

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