Diphenylpyrazoles as Replication Protein A Inhibitors

Waterson, Alex G.; Kennedy, J. Phillip; Patrone, James D.; Pelz, Nicholas F.; Feldkamp, Michael D.; Frank, Andreas O.; Vangamudi, Bhavatarini; Souza-Fagundes, Elaine M.; Rossanese, Olivia W.; Chazin, Walter J.; Fesik, Stephen W.

doi:10.1021/ml5003629

Diphenylpyrazoles as Replication Protein A Inhibitors

Journal Article · Tue Dec 02 04:00:00 EST 2014 · ACS Medicinal Chemistry Letters

DOI:https://doi.org/10.1021/ml5003629· OSTI ID:1497143

Waterson, Alex G. ^[1]; Kennedy, J. Phillip ^[1]; Patrone, James D. ^[1]; Pelz, Nicholas F. ^[1]; Feldkamp, Michael D. ^[1]; Frank, Andreas O. ^[1]; Vangamudi, Bhavatarini ^[1]; Souza-Fagundes, Elaine M. ^[1]; Rossanese, Olivia W. ^[1]; Chazin, Walter J. ^[1]; Fesik, Stephen W. ^[1]

Department of Biochemistry, ‡Department of Pharmacology, Vanderbilt University School of Medicine, and §Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States

Abstract not provided

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: NIH

OSTI ID:: 1497143

Journal Information:: ACS Medicinal Chemistry Letters, Journal Name: ACS Medicinal Chemistry Letters Journal Issue: 2 Vol. 6; ISSN 1948-5875

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: ENGLISH

References (12)

REPLICATION PROTEIN A:A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism Wold, Marc S. Annual Review of Biochemistry, Vol. 66, Issue 1 https://doi.org/10.1146/annurev.biochem.66.1.61	journal	June 1997
Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA. Wold, M. S.; Kelly, T. Proceedings of the National Academy of Sciences, Vol. 85, Issue 8 https://doi.org/10.1073/pnas.85.8.2523	journal	April 1988
A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A Souza-Fagundes, Elaine M.; Frank, Andreas O.; Feldkamp, Michael D. Analytical Biochemistry, Vol. 421, Issue 2 https://doi.org/10.1016/j.ab.2011.11.025	journal	February 2012
The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling Xu, X.; Vaithiyalingam, S.; Glick, G. G. Molecular and Cellular Biology, Vol. 28, Issue 24 https://doi.org/10.1128/MCB.01079-08	journal	October 2008
A dynamic model for replication protein A (RPA) function in DNA processing pathways Fanning, E. Nucleic Acids Research, Vol. 34, Issue 15 https://doi.org/10.1093/nar/gkl550	journal	August 2006
ATR and ATRIP: Partners in Checkpoint Signaling Cortez, D. Science, Vol. 294, Issue 5547 https://doi.org/10.1126/science.1065521	journal	November 2001
ATR: an essential regulator of genome integrity Cimprich, Karlene A.; Cortez, David Nature Reviews Molecular Cell Biology, Vol. 9, Issue 8 https://doi.org/10.1038/nrm2450	journal	July 2008
Discovery of Protein–Protein Interaction Inhibitors of Replication Protein A Patrone, James D.; Kennedy, J. Phillip; Frank, Andreas O. ACS Medicinal Chemistry Letters, Vol. 4, Issue 7 https://doi.org/10.1021/ml400032y	journal	May 2013
Compound Design by Fragment-Linking Ichihara, Osamu; Barker, John; Law, Richard J. Molecular Informatics, Vol. 30, Issue 4 https://doi.org/10.1002/minf.201000174	journal	April 2011
Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A Frank, Andreas O.; Vangamudi, Bhavatarini; Feldkamp, Michael D. Journal of Medicinal Chemistry, Vol. 57, Issue 6 https://doi.org/10.1021/jm401730y	journal	February 2014
RPA Inhibition Increases Replication Stress and Suppresses Tumor Growth Glanzer, J. G.; Liu, S.; Wang, L. Cancer Research, Vol. 74, Issue 18 https://doi.org/10.1158/0008-5472.CAN-14-0306	journal	July 2014
Discovery of a Potent Inhibitor of Replication Protein A Protein–Protein Interactions Using a Fragment-Linking Approach Frank, Andreas O.; Feldkamp, Michael D.; Kennedy, J. Phillip Journal of Medicinal Chemistry, Vol. 56, Issue 22 https://doi.org/10.1021/jm401333u	journal	November 2013

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Design and synthesis of novel ditopic ligands with a pyrazole ring in the central unit Bratanovici, Bogdan-Ionel; Nicolescu, Alina; Shova, Sergiu Research on Chemical Intermediates, Vol. 46, Issue 2 https://doi.org/10.1007/s11164-019-04052-3	journal	December 2019

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