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Reproducible automated renewable column generation

Journal Article · · Separation Science and Technology
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  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Elemental Scientific Inc., Omaha, NE (United States)
+ Show Author Affiliations
Preparation of chromatographic columns requires considerable time during chemical separation procedures. Automated systems capable of repeatedly generating renewable, uniformly packed columns would find widespread use in analytical laboratories. Here, a fully automated commercial-off-the-shelf (COTS) system was utilized to pack and unpack 1 mL TEVA and UTEVA columns. To accurately determine the reproducibility of the resin load per column, studies were conducted over several weeks. Method optimization yielded an improvement in loading from 15–19% to 3–5% relative standard deviation. Furthermore, availability of automated COTS equipment capable of reproducibly generating separation columns has the potential to reduce time and costs associated with column separation.
Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA)
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1496014
Journal Information:
Separation Science and Technology, Journal Name: Separation Science and Technology Journal Issue: 5 Vol. 55; ISSN 0149-6395
Publisher:
Taylor & FrancisCopyright Statement
Country of Publication:
United States
Language:
English

References (10)

Development of a relatively cheap and simple automated separation system for a routine separation procedure based on extraction chromatography journal June 2010
Automated pressurized injection system for the separation of actinides by extraction chromatography journal August 2012
Bead Injection Extraction Chromatography Using High-Capacity Lab-on-Valve as a Front End to Inductively Coupled Plasma Mass Spectrometry for Urine Radiobioassay journal February 2013
Automated Analysis of Radionuclides in Nuclear Waste:  Rapid Determination of 90 Sr by Sequential Injection Analysis journal January 1996
Titration without Mixing or Dilution:  Sequential Injection of Chemical Sensing Membranes journal May 1997
Sequential Injection Renewable Separation Column Instrument for Automated Sorbent Extraction Separations of Radionuclides journal December 1998
Peer Reviewed: From Flow Injection to Bead Injection. journal April 1999
Fully automated chromatographic purification of Sr and Ca for isotopic analysis journal January 2015
An automated chromatography procedure optimized for analysis of stable Cu isotopes from biological materials journal January 2016
Automated solid phase extraction of theophylline by sequential injection on renewable column journal January 1998

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Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
automated
column packing
renewable column
safeguards