Does co-transcriptional regulation of alternative splicing mediate plant stress responses?

Jabre, Ibtissam; Reddy, Anireddy S. N.; Kalyna, Maria; Chaudhary, Saurabh; Khokhar, Waqas; Byrne, Lee J.; Wilson, Cornelia M.; Syed, Naeem H.

doi:10.1093/nar/gkz121

Title: Does co-transcriptional regulation of alternative splicing mediate plant stress responses?

Journal Article · Fri Feb 22 00:00:00 EST 2019 · Nucleic Acids Research

DOI:https://doi.org/10.1093/nar/gkz121· OSTI ID:1495855

Jabre, Ibtissam ^[1]; Reddy, Anireddy S. N. ^[2];

^[3]; Chaudhary, Saurabh ^[1]; Khokhar, Waqas ^[1]; Byrne, Lee J. ^[1];

^[1];

^[1]

School of Human and Life Sciences, Canterbury Christ Church University, Canterbury, CT1 1QU, UK
Department of Biology and Program in Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1878, USA
Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences - BOKU, Muthgasse 18, 1190 Vienna, Austria

Plants display exquisite control over gene expression to elicit appropriate responses under normal and stress conditions. Alternative splicing (AS) of pre-mRNAs, a process that generates two or more transcripts from multi-exon genes, adds another layer of regulation to fine-tune condition-specific gene expression in animals and plants. However, exactly how plants control splice isoform ratios and the timing of this regulation in response to environmental signals remains elusive. In mammals, recent evidence indicate that epigenetic and epitranscriptome changes, such as DNA methylation, chromatin modifications and RNA methylation, regulate RNA polymerase II processivity, co-transcriptional splicing, and stability and translation efficiency of splice isoforms. In plants, the role of epigenetic modifications in regulating transcription rate and mRNA abundance under stress is beginning to emerge. However, the mechanisms by which epigenetic and epitranscriptomic modifications regulate AS and translation efficiency require further research. Dynamic changes in the chromatin landscape in response to stress may provide a scaffold around which gene expression, AS and translation are orchestrated. Finally, we discuss CRISPR/Cas-based strategies for engineering chromatin architecture to manipulate AS patterns (or splice isoforms levels) to obtain insight into the epigenetic regulation of AS.

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Research Organization:: Colorado State Univ., Fort Collins, CO (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0010733

OSTI ID:: 1495855

Alternate ID(s):: OSTI ID: 1611510

Journal Information:: Nucleic Acids Research, Journal Name: Nucleic Acids Research Vol. 47 Journal Issue: 6; ISSN 0305-1048

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Cited by: 52 works

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