Hydroxyapatite Nanocrystal Deposited Titanium Dioxide Nanotubes Loaded with Antibiotics for Combining Biocompatibility and Antibacterial Properties

Journal Article · Sun Jan 28 00:00:00 EST 2018 · MRS Advances

DOI:https://doi.org/10.1557/adv.2018.114· OSTI ID:1494560

Zhang, Xuefei ^[1]; Zhang, Yuan ^[2]; Yates, Matthew Z. ^[2]

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1. Univ. of Rochester, NY (United States). Materials Science Program
2. Univ. of Rochester, NY (United States). Dept. of Chemical Engineering

Hydroxyapatite (HA)/nanotubular titanium dioxide (TiO₂) composite coatings loaded with antibiotics were developed here to combine biocompatibility and antibacterial property. TiO₂ nanotubes were first fabricated on Ti plates using anodization techniques. Then HA nanocrystals were synthesized on the TiO₂ nanotubes by electrochemical deposition, followed by loading of a model drug compound, streptomycin. The streptomycin release profile of the composite coating was investigated. Bacterial tests demonstrate that the streptomycin-loaded composite coatings were highly effective in inhibiting bacterial growth. Simulated body fluid (SBF) experiments indicated that the composite coatings possessed good osseointegration capability.

• Research Organization: Univ. of Rochester, NY (United States)
• Sponsoring Organization: USDOE National Nuclear Security Administration (NNSA); National Science Foundation (NSF)
• Grant/Contract Number: NA0001944; CMMI-0856128; IIP-1343083; CHE-1427882
• OSTI ID: 1494560
• Journal Information: MRS Advances, Vol. 3, Issue 30; ISSN 2059-8521
• Publisher: Materials Research Society (MRS)
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
biomaterial
coating
electrochemical synthesis