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Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

Journal Article · · Journal of Biological Chemistry
Abstract not provided
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
NIHFOREIGNOTHER
OSTI ID:
1493796
Journal Information:
Journal of Biological Chemistry, Journal Name: Journal of Biological Chemistry Journal Issue: 3 Vol. 294; ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology
Country of Publication:
United States
Language:
ENGLISH

References (42)

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern journal October 2012
AMPK: a nutrient and energy sensor that maintains energy homeostasis journal March 2012
AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer journal June 2013
Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells journal August 2017
Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing journal June 2017
Coordinated regulation of AMPK activity by multiple elements in the α-subunit journal September 2013
Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase journal September 2007
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome journal June 2006
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase journal May 2009
Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms journal August 2014
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status journal September 2011
Identification of a Novel AMP-activated Protein Kinase β Subunit Isoform That Is Highly Expressed in Skeletal Muscle journal May 1998
Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle: Differential AMPK trimer activation in muscle journal December 2006
Phaser crystallographic software journal July 2007
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy journal July 2017
A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation journal February 2014
Structural basis of AMPK regulation by adenine nucleotides and glycogen journal November 2014
HDX Workbench: Software for the Analysis of H/D Exchange MS Data journal June 2012
Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes journal November 2008
Metformin: From Mechanisms of Action to Therapies journal December 2014
Conserved regulatory elements in AMPK journal June 2013
Targeting an energy sensor to treat diabetes journal August 2017
The Recruitment of AMP-activated Protein Kinase to Glycogen Is Regulated by Autophosphorylation journal March 2015
AMPK in Health and Disease journal July 2009
Effect of different γ-subunit isoforms on the regulation of AMPK journal May 2017
Coot model-building tools for molecular graphics journal November 2004
Metformin Action: Concentrations Matter journal February 2015
Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding journal March 2000
Structural basis for AMP binding to mammalian AMP-activated protein kinase journal September 2007
Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling journal May 2014
AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs journal March 2016
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase journal July 2005
Metformin Activates AMP-activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex journal December 2014
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice journal May 2017
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes journal June 2012
The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine journal March 2018
AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation journal October 2013
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade journal March 2007
Structural basis of AMPK regulation by small molecule activators journal December 2013
Metformin Activates AMPK through the Lysosomal Pathway journal October 2016
Structure of mammalian AMPK and its regulation by ADP journal March 2011
Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK) journal June 2014

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