Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor

Journal Article · Wed Nov 21 00:00:00 EST 2018 · ACS Medicinal Chemistry Letters

DOI:https://doi.org/10.1021/acsmedchemlett.8b00487· OSTI ID:1493789

Porter, Nicholas J. ^[1]; Shen, Sida  ^[2]; Barinka, Cyril  ^[3]; Kozikowski, Alan P. ^[4]; Christianson, David W.  ^[1]

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1. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States
2. Department of Medicinal Chemistry and Pharmacognosy, Drug Discovery Program, University of Illinois at Chicago, Chicago, Illinois 60612, United States
3. Laboratory of Structural Biology, Institute of Biotechnology of the Czech Academy of Sciences, Prumyslova 595, 252 50 Vestec, Czech Republic
4. StarWise Therapeutics LLC, 505 South Rosa Road, Madison, Wisconsin 53719, United States

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: USDOE Office of Science (SC)
• OSTI ID: 1493789
• Journal Information: ACS Medicinal Chemistry Letters, Vol. 9, Issue 12; ISSN 1948-5875
• Publisher: American Chemical Society (ACS)
• Country of Publication: United States
• Language: ENGLISH