Versatile Ligand-Exchange Method for the Synthesis of Water-Soluble Monodisperse AuAg Nanoclusters for Cancer Therapy

Zan, Xiaofeng; Li, Qinzhen; Pan, Yiting; Morris, David J.; Zhang, Peng; Li, Peng; Yu, Haizhu; Zhu, Manzhou

doi:10.1021/acsanm.8b01559

Versatile Ligand-Exchange Method for the Synthesis of Water-Soluble Monodisperse AuAg Nanoclusters for Cancer Therapy

Journal Article · Wed Nov 14 00:00:00 EST 2018 · ACS Applied Nano Materials

DOI:https://doi.org/10.1021/acsanm.8b01559· OSTI ID:1491881

Zan, Xiaofeng ^[1]; Li, Qinzhen ^[1]; Pan, Yiting ^[1]; Morris, David J. ^[2]; ^[2]; ^[1]; ^[3]; ^[1]

Anhui Univ., Hefei (China)
Dalhousie Univ. (Canada)
Anhui Univ., Hefei (China); Peking Univ., Beijing (China)

A general-applicable two-phase ligand exchange method is developed to prepare a series of monodisperse water-soluble AuAg nanoclusters. This method relies on the ligand exchange of the water-soluble ligands (e.g., tiopronin, captopril, N-acetyl-l-cysteine, 4-mercaptobenzoic acid, glutathione, and mercaptosuccinic acid) with phenylacetylene and triphenylphosphine co-protected AuAg precursors. Both polyacrylamide gel electrophoresis (PAGE) and transmission electron microscopy (TEM) indicate the monodispersity and ultrasmall size of the prepared water-soluble metal nanoclusters. In addition, the structure has also been characterized by UV–vis absorption spectroscopy, extended X-ray absorption fine structure (EXAFS), electrospray ionization time-of-flight mass spectra (ESI-TOF-MS), etc. The preliminary application of the as-prepared AuAg nanoclusters protected with tiopronin has been explored via the postmodification of the carboxyl groups of thiols with doxorubicin (DOX).

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: USDOE Office of Science (SC)

OSTI ID:: 1491881

Journal Information:: ACS Applied Nano Materials, Journal Name: ACS Applied Nano Materials Journal Issue: 12 Vol. 1; ISSN 2574-0970

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: ENGLISH

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