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Title: Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

Authors:
 [1];  [2];  [3];  [3];  [4];  [3];  [3];  [5];  [2];  [2];  [1];  [6]; ORCiD logo [3]
  1. Departments of Chemistry and Global Health, University of Washington, 36 Bagley Hall, 400 15th Avenue NE, Seattle, Washington 98195, United States
  2. Department of Microbiology &, Immunology, Columbia University Irving Medical Center, 701 West 168th Street, HHSC 1502, New York, New York 10032, United States
  3. Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States
  4. Department of Microbiology &, Immunology, Columbia University Irving Medical Center, 701 West 168th Street, HHSC 1502, New York, New York 10032, United States; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, U.K.
  5. Department of Biophysics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States
  6. Department of Microbiology &, Immunology, Columbia University Irving Medical Center, 701 West 168th Street, HHSC 1502, New York, New York 10032, United States; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, PH8-W, 630 West 168th Street, PH 8-West, New York, New York 10032, United States
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NIHOTHER
OSTI Identifier:
1491867
Resource Type:
Journal Article
Journal Name:
ACS Infectious Diseases
Additional Journal Information:
Journal Volume: 5; Journal Issue: 1; Journal ID: ISSN 2373-8227
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

White, John, Dhingra, Satish K., Deng, Xiaoyi, El Mazouni, Farah, Lee, Marcus C. S., Afanador, Gustavo A., Lawong, Aloysus, Tomchick, Diana R., Ng, Caroline L., Bath, Jade, Rathod, Pradipsinh K., Fidock, David A., and Phillips, Margaret A. Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. United States: N. p., 2018. Web. doi:10.1021/acsinfecdis.8b00211.
White, John, Dhingra, Satish K., Deng, Xiaoyi, El Mazouni, Farah, Lee, Marcus C. S., Afanador, Gustavo A., Lawong, Aloysus, Tomchick, Diana R., Ng, Caroline L., Bath, Jade, Rathod, Pradipsinh K., Fidock, David A., & Phillips, Margaret A. Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. United States. doi:10.1021/acsinfecdis.8b00211.
White, John, Dhingra, Satish K., Deng, Xiaoyi, El Mazouni, Farah, Lee, Marcus C. S., Afanador, Gustavo A., Lawong, Aloysus, Tomchick, Diana R., Ng, Caroline L., Bath, Jade, Rathod, Pradipsinh K., Fidock, David A., and Phillips, Margaret A. Tue . "Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265". United States. doi:10.1021/acsinfecdis.8b00211.
@article{osti_1491867,
title = {Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265},
author = {White, John and Dhingra, Satish K. and Deng, Xiaoyi and El Mazouni, Farah and Lee, Marcus C. S. and Afanador, Gustavo A. and Lawong, Aloysus and Tomchick, Diana R. and Ng, Caroline L. and Bath, Jade and Rathod, Pradipsinh K. and Fidock, David A. and Phillips, Margaret A.},
abstractNote = {},
doi = {10.1021/acsinfecdis.8b00211},
journal = {ACS Infectious Diseases},
issn = {2373-8227},
number = 1,
volume = 5,
place = {United States},
year = {2018},
month = {10}
}