A Cu‐mediated ortho ‐C−H radiofluorination of aromatic carboxylic acids that are protected as 8‐aminoquinoline benzamides is described. The method uses K 18 F and is compatible with a wide range of functional groups. The reaction is showcased in the high specific activity automated synthesis of the RARβ2 agonist [ 18 F]AC261066.
Lee, So Jeong, et al. "Copper‐Mediated Aminoquinoline‐Directed Radiofluorination of Aromatic C−H Bonds with K <sup>18</sup> F." Angewandte Chemie (International Edition), vol. 58, no. 10, Jan. 2019. https://doi.org/10.1002/anie.201812701
Lee, So Jeong, Makaravage, Katarina J., Brooks, Allen F., Scott, Peter J. H., & Sanford, Melanie S. (2019). Copper‐Mediated Aminoquinoline‐Directed Radiofluorination of Aromatic C−H Bonds with K <sup>18</sup> F. Angewandte Chemie (International Edition), 58(10). https://doi.org/10.1002/anie.201812701
Lee, So Jeong, Makaravage, Katarina J., Brooks, Allen F., et al., "Copper‐Mediated Aminoquinoline‐Directed Radiofluorination of Aromatic C−H Bonds with K <sup>18</sup> F," Angewandte Chemie (International Edition) 58, no. 10 (2019), https://doi.org/10.1002/anie.201812701
@article{osti_1491271,
author = {Lee, So Jeong and Makaravage, Katarina J. and Brooks, Allen F. and Scott, Peter J. H. and Sanford, Melanie S.},
title = {Copper‐Mediated Aminoquinoline‐Directed Radiofluorination of Aromatic C−H Bonds with K <sup>18</sup> F},
annote = {Abstract A Cu‐mediated ortho ‐C−H radiofluorination of aromatic carboxylic acids that are protected as 8‐aminoquinoline benzamides is described. The method uses K 18 F and is compatible with a wide range of functional groups. The reaction is showcased in the high specific activity automated synthesis of the RARβ2 agonist [ 18 F]AC261066. },
doi = {10.1002/anie.201812701},
url = {https://www.osti.gov/biblio/1491271},
journal = {Angewandte Chemie (International Edition)},
issn = {ISSN 1433-7851},
number = {10},
volume = {58},
place = {Germany},
publisher = {Wiley Blackwell (John Wiley & Sons)},
year = {2019},
month = {01}}