Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity

Journal Article · Sun Jul 01 00:00:00 EDT 2018 · Protein Engineering, Design and Selection

DOI:https://doi.org/10.1093/protein/gzy022· OSTI ID:1488939

Rudolph, Michael J. ^[1]; Vance, David J. ^[2]; Kelow, Simon ^[3]; Angalakurthi, Siva Krishna ^[4]; Nguyen, Sophie ^[1]; Davis, Simon A. ^[1]; Rong, Yinghui ^[2]; Middaugh, C. Russell ^[4]; Weis, David D. ^[5]; Dunbrack, Roland ^[6]; Karanicolas, John ^[6]; Mantis, Nicholas J.  ^[2]; Huston, James

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1. New York Structural Biology Center, New York, NY, USA
2. Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA
3. Department of Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, PA, USA
4. Department of Pharmaceutical Chemistry and Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, KS, USA
5. Department of Chemistry and Ralph Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, KS, USA
6. Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: NIHNIAIDNIGMS
• OSTI ID: 1488939
• Journal Information: Protein Engineering, Design and Selection, Vol. 31, Issue 7-8; ISSN 1741-0126
• Country of Publication: United States
• Language: ENGLISH