Microbial communities for bioprocessing: lessons learned from nature

Peng, Xuefeng “Nick”; Gilmore, Sean P.; O’Malley, Michelle A.

doi:10.1016/j.coche.2016.09.003

Microbial communities for bioprocessing: lessons learned from nature

Journal Article · Wed Sep 28 00:00:00 EDT 2016 · Current Opinion in Chemical Engineering

DOI:https://doi.org/10.1016/j.coche.2016.09.003· OSTI ID:1485169

Peng, Xuefeng “Nick” ^[1]; Gilmore, Sean P. ^[2]; O’Malley, Michelle A. ^[2]

Univ. of California, Santa Barbara, CA (United States). Dept. of Chemical Engineering. Dept. of Earth Science; UCSB
Univ. of California, Santa Barbara, CA (United States). Dept. of Chemical Engineering

Microbial bioprocessing has evolved from the use of undefined natural consortia to the construction of synthetic communities tailored to specific processes and bioproducts. This evolution is enabled by recent advances in biotechnology, including cultivation of non-model microbes, metabolic engineering, bioinformatics, and numerical modeling. Equipped with these powerful tools, engineers have designed co-cultures and consortia with an expanded set of capabilities, mainly via ‘bottom-up’ approaches that tether isolates together in culture. We present a brief review of the opportunities, challenges, and recent developments in consortia-based bioprocessing with a focus on lignocellulosic biomass conversion. With improved understanding of microbial community composition and function, we further present a vision to harness defined consortia down-selected from nature via ‘top down’ approaches.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of California, Santa Barbara, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); Army Research Office (ARO) (United States); National Science Foundation (NSF) (United States)

Grant/Contract Number:: SC0010352

OSTI ID:: 1485169

Alternate ID(s):: OSTI ID: 1358965

Journal Information:: Current Opinion in Chemical Engineering, Journal Name: Current Opinion in Chemical Engineering Vol. 14; ISSN 2211-3398

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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