Direct observation of conformational dynamics of the PH domain in phospholipases Cϵ and β may contribute to subfamily-specific roles in regulation

Garland-Kuntz, Elisabeth E.; Vago, Frank S.; Sieng, Monita; Van Camp, Michelle; Chakravarthy, Srinivas; Blaine, Arryn; Corpstein, Clairissa; Jiang, Wen; Lyon, Angeline M.

doi:10.1074/jbc.RA118.003656

Title: Direct observation of conformational dynamics of the PH domain in phospholipases Cϵ and β may contribute to subfamily-specific roles in regulation

Journal Article · Fri Sep 21 00:00:00 EDT 2018 · Journal of Biological Chemistry

DOI:https://doi.org/10.1074/jbc.RA118.003656· OSTI ID:1483070

Garland-Kuntz, Elisabeth E.; Vago, Frank S.; Sieng, Monita; Van Camp, Michelle; Chakravarthy, Srinivas; Blaine, Arryn; Corpstein, Clairissa; Jiang, Wen;

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: NIHAHA

OSTI ID:: 1483070

Journal Information:: Journal of Biological Chemistry, Vol. 293, Issue 45; ISSN 0021-9258

Publisher:: American Society for Biochemistry and Molecular Biology

Country of Publication:: United States

Language:: ENGLISH

References (59)

Structural Insights into Phospholipase C- β Function Lyon, Angeline M.; Tesmer, John J. G. Molecular Pharmacology, Vol. 84, Issue 4 https://doi.org/10.1124/mol.113.087403	journal	July 2013
Dual Activation of Phospholipase C-ϵ by Rho and Ras GTPases Seifert, Jason P.; Zhou, Yixing; Hicks, Stephanie N. Journal of Biological Chemistry, Vol. 283, Issue 44 https://doi.org/10.1074/jbc.M805038200	journal	September 2008
Uniqueness of ab initio shape determination in small-angle scattering Volkov, Vladimir V.; Svergun, Dmitri I. Journal of Applied Crystallography, Vol. 36, Issue 3, p. 860-864 https://doi.org/10.1107/S0021889803000268	journal	April 2003
Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2 Kimanius, Dari; Forsberg, Björn O.; Scheres, Sjors HW eLife, Vol. 5 https://doi.org/10.7554/eLife.18722	journal	November 2016
Global Rigid Body Modeling of Macromolecular Complexes against Small-Angle Scattering Data Petoukhov, Maxim V.; Svergun, Dmitri I. Biophysical Journal, Vol. 89, Issue 2 https://doi.org/10.1529/biophysj.105.064154	journal	August 2005
The atypical ‘b’ splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction Grubb, David R.; Crook, Bryony; Ma, Yi Journal of Molecular and Cellular Cardiology, Vol. 84 https://doi.org/10.1016/j.yjmcc.2015.04.016	journal	July 2015
CRYSOL – a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates Svergun, D.; Barberato, C.; Koch, M. H. J. Journal of Applied Crystallography, Vol. 28, Issue 6 https://doi.org/10.1107/S0021889895007047	journal	December 1995
Accuracy of molecular mass determination of proteins in solution by small-angle X-ray scattering Mylonas, Efstratios; Svergun, Dmitri I. Journal of Applied Crystallography, Vol. 40, Issue s1 https://doi.org/10.1107/S002188980700252X	journal	February 2007
Determination of the regularization parameter in indirect-transform methods using perceptual criteria Svergun, D. I. Journal of Applied Crystallography, Vol. 25, Issue 4, p. 495-503 https://doi.org/10.1107/S0021889892001663	journal	August 1992
The Pleckstrin Homology Domains of Phospholipases C-β and -δ Confer Activation through a Common Site Guo, Yuanjian; Philip, Finly; Scarlata, Suzanne Journal of Biological Chemistry, Vol. 278, Issue 32 https://doi.org/10.1074/jbc.M301438200	journal	May 2003
BioXTAS RAW : improvements to a free open-source program for small-angle X-ray scattering data reduction and analysis Hopkins, Jesse Bennett; Gillilan, Richard E.; Skou, Soren Journal of Applied Crystallography, Vol. 50, Issue 5 https://doi.org/10.1107/S1600576717011438	journal	September 2017
A Dynamic Model of Membrane-Bound Phospholipase Cβ2 Activation by Gβγ Subunits Han, Daniel S.; Golebiewska, Urszula; Stolzenberg, Sebastian Molecular Pharmacology, Vol. 80, Issue 3 https://doi.org/10.1124/mol.111.073403	journal	June 2011
ATSAS 2.8 : a comprehensive data analysis suite for small-angle scattering from macromolecular solutions Franke, D.; Petoukhov, M. V.; Konarev, P. V. Journal of Applied Crystallography, Vol. 50, Issue 4 https://doi.org/10.1107/S1600576717007786	journal	June 2017
PRIMUS: a Windows PC-based system for small-angle scattering data analysis Konarev, Petr V.; Volkov, Vladimir V.; Sokolova, Anna V. Journal of Applied Crystallography, Vol. 36, Issue 5, p. 1277-1282 https://doi.org/10.1107/S0021889803012779	journal	September 2003
Determination of protein oligomeric structure from small-angle X-ray scattering: Determination of Protein Oligomeric Structure from SAXS Korasick, David A.; Tanner, John J. Protein Science, Vol. 27, Issue 4 https://doi.org/10.1002/pro.3376	journal	February 2018
G protein βγ subunits directly interact with and activate phospholipase Cϵ Madukwe, Jerry C.; Garland-Kuntz, Elisabeth E.; Lyon, Angeline M. Journal of Biological Chemistry, Vol. 293, Issue 17 https://doi.org/10.1074/jbc.RA118.002354	journal	March 2018
Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site Kadamur, Ganesh; Ross, Elliott M. Journal of Biological Chemistry, Vol. 291, Issue 21 https://doi.org/10.1074/jbc.M116.723940	journal	March 2016
A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq Singer, Alex U.; Waldo, Gary L.; Harden, T. Kendall Nature Structural Biology, Vol. 9, Issue 1 https://doi.org/10.1038/nsb731	journal	November 2001
Role of phospholipase Cε in physiological phosphoinositide signaling networks Smrcka, Alan V.; Brown, Joan Heller; Holz, George G. Cellular Signalling, Vol. 24, Issue 6 https://doi.org/10.1016/j.cellsig.2012.01.009	journal	June 2012
An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation Lyon, Angeline M.; Tesmer, Valerie M.; Dhamsania, Vishan D. Nature Structural & Molecular Biology, Vol. 18, Issue 9 https://doi.org/10.1038/nsmb.2095	journal	August 2011
Negative staining and image classification — powerful tools in modern electron microscopy Ohi, Melanie; Li, Ying; Cheng, Yifan Biological Procedures Online, Vol. 6, Issue 1 https://doi.org/10.1251/bpo70	journal	January 2004
Molecular Mechanisms of Phospholipase C β3 Autoinhibition Lyon, Angeline M.; Begley, Jessica A.; Manett, Taylor D. Structure, Vol. 22, Issue 12 https://doi.org/10.1016/j.str.2014.10.008	journal	December 2014
Full-length Gαq–phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain Lyon, Angeline M.; Dutta, Somnath; Boguth, Cassandra A. Nature Structural & Molecular Biology, Vol. 20, Issue 3 https://doi.org/10.1038/nsmb.2497	journal	February 2013
Epac and Phospholipase Cϵ Regulate Ca ²⁺ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II Oestreich, Emily A.; Malik, Sundeep; Goonasekera, Sanjeewa A. Journal of Biological Chemistry, Vol. 284, Issue 3 https://doi.org/10.1074/jbc.M806994200	journal	October 2008
Regulation of Phosphatidylinositol-specific Phospholipase C at the Nuclear Envelope in Cardiac Myocytes Smrcka, Alan V. Journal of Cardiovascular Pharmacology, Vol. 65, Issue 3 https://doi.org/10.1097/FJC.0000000000000195	journal	January 2015
UCSF Chimera?A visualization system for exploratory research and analysis Pettersen, Eric F.; Goddard, Thomas D.; Huang, Conrad C. Journal of Computational Chemistry, Vol. 25, Issue 13 https://doi.org/10.1002/jcc.20084	journal	January 2004
Epac-mediated Activation of Phospholipase Cϵ Plays a Critical Role in β-Adrenergic Receptor-dependent Enhancement of Ca ²⁺ Mobilization in Cardiac Myocytes Oestreich, Emily A.; Wang, Huan; Malik, Sundeep Journal of Biological Chemistry, Vol. 282, Issue 8 https://doi.org/10.1074/jbc.M608495200	journal	December 2006
Direct Activation of Purified Phospholipase C Epsilon by RhoA Studied in Reconstituted Phospholipid Vesicles Seifert, Jason P.; Snyder, Jason T.; Sondek, John Methods in Enzymology https://doi.org/10.1016/S0076-6879(06)06019-8	book	January 2006
Gq-initiated cardiomyocyte hypertrophy is mediated by phospholipase Cβ1b Filtz, Theresa M.; Grubb, David R.; McLeod-Dryden, Tiffany J. The FASEB Journal, Vol. 23, Issue 10 https://doi.org/10.1096/fj.09-133983	journal	October 2009
Role of the CDC25 Homology Domain of Phospholipase Cε in Amplification of Rap1-dependent Signaling Jin, Tai-Guang; Satoh, Takaya; Liao, Yanhong Journal of Biological Chemistry, Vol. 276, Issue 32 https://doi.org/10.1074/jbc.M103530200	journal	June 2001
Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy Zhang, Lianghui; Malik, Sundeep; Pang, Jinjiang Cell, Vol. 153, Issue 1 https://doi.org/10.1016/j.cell.2013.02.047	journal	March 2013
Crystal structure of Rac1 bound to its effector phospholipase C-β2 Jezyk, Mark R.; Snyder, Jason T.; Gershberg, Svetlana Nature Structural & Molecular Biology, Vol. 13, Issue 12 https://doi.org/10.1038/nsmb1175	journal	November 2006
EMAN2: An extensible image processing suite for electron microscopy Tang, Guang; Peng, Liwei; Baldwin, Philip R. Journal of Structural Biology, Vol. 157, Issue 1 https://doi.org/10.1016/j.jsb.2006.05.009	journal	January 2007
Phospholipase Cϵ Scaffolds to Muscle-specific A Kinase Anchoring Protein (mAKAPβ) and Integrates Multiple Hypertrophic Stimuli in Cardiac Myocytes Zhang, Lianghui; Malik, Sundeep; Kelley, Grant G. Journal of Biological Chemistry, Vol. 286, Issue 26 https://doi.org/10.1074/jbc.M111.231993	journal	May 2011
The Role of Carboxyl-terminal Basic Amino Acids in G _q α-dependent Activation, Particulate Association, and Nuclear Localization of Phospholipase C-β1 Kim, Chan Gil; Park, Dongeun; Rhee, Sue Goo Journal of Biological Chemistry, Vol. 271, Issue 35 https://doi.org/10.1074/jbc.271.35.21187	journal	August 1996
Phospholipase Cβ3 Membrane Adsorption and Activation Are Regulated by Its C-Terminal Domains and Phosphatidylinositol 4,5-Bisphosphate Hudson, Brianna N.; Hyun, Seok-Hee; Thompson, David H. Biochemistry, Vol. 56, Issue 41 https://doi.org/10.1021/acs.biochem.7b00547	journal	May 2017
The Pleckstrin Homology Domain of Phospholipase Cβ Transmits Enzymatic Activation through Modulation of the Membrane−Domain Orientation ^† Drin, Guillaume; Douguet, Dominique; Scarlata, Suzanne Biochemistry, Vol. 45, Issue 18 https://doi.org/10.1021/bi052317n	journal	May 2006
Synchrotron-based small-angle X-ray scattering of proteins in solution Skou, Soren; Gillilan, Richard E.; Ando, Nozomi Nature Protocols, Vol. 9, Issue 7 https://doi.org/10.1038/nprot.2014.116	journal	June 2014
General and Versatile Autoinhibition of PLC Isozymes Hicks, Stephanie N.; Jezyk, Mark R.; Gershburg, Svetlana Molecular Cell, Vol. 31, Issue 3 https://doi.org/10.1016/j.molcel.2008.06.018	journal	August 2008
2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update Trewhella, Jill; Duff, Anthony P.; Durand, Dominique Acta Crystallographica Section D Structural Biology, Vol. 73, Issue 9 https://doi.org/10.1107/S2059798317011597	journal	August 2017
Restoring Low Resolution Structure of Biological Macromolecules from Solution Scattering Using Simulated Annealing Svergun, D. I. Biophysical Journal, Vol. 76, Issue 6, p. 2879-2886 https://doi.org/10.1016/S0006-3495(99)77443-6	journal	June 1999
Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins Kelley, Grant G.; Reks, Sarah E.; Smrcka, Alan V. Biochemical Journal, Vol. 378, Issue 1 https://doi.org/10.1042/bj20031370	journal	February 2004
RhoA Activates Purified Phospholipase C-ϵ by a Guanine Nucleotide-dependent Mechanism Seifert, Jason P.; Wing, Michele R.; Snyder, Jason T. Journal of Biological Chemistry, Vol. 279, Issue 46 https://doi.org/10.1074/jbc.M407111200	journal	August 2004
Mutations in the Carboxyl-terminal Domain of Phospholipase C-β1 Delineate the Dimer Interface and a Potential Gα _q Interaction Site Ilkaeva, Olga; Kinch, Lisa N.; Paulssen, Ruth H. Journal of Biological Chemistry, Vol. 277, Issue 6 https://doi.org/10.1074/jbc.M109612200	journal	November 2001
Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase Glukhova, Alisa; Hinkovska-Galcheva, Vania; Kelly, Robert Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms7250	journal	March 2015
Reassembly of Phospholipase C-β ₂ from Separated Domains : ANALYSIS OF BASAL AND G PROTEIN-STIMULATED ACTIVITIES Zhang, Wei; Neer, Eva J. Journal of Biological Chemistry, Vol. 276, Issue 4 https://doi.org/10.1074/jbc.M003562200	journal	October 2000
Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ Essen, Lars-Oliver; Perisic, Olga; Cheung, Robert Nature, Vol. 380, Issue 6575 https://doi.org/10.1038/380595a0	journal	April 1996
Enhancing Recombinant Protein Quality and Yield by Protein Stability Profiling Mezzasalma, Tara M.; Kranz, James K.; Chan, Winnie Journal of Biomolecular Screening, Vol. 12, Issue 3 https://doi.org/10.1177/1087057106297984	journal	April 2007
The pleckstrin homology domain of phospholipase C-.delta.1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes Garcia, Pilar; Gupta, Rakesh; Shah, Shefali Biochemistry, Vol. 34, Issue 49 https://doi.org/10.1021/bi00049a039	journal	December 1995
Stimulation of phospholipase C by guanine-nucleotide-binding protein betagamma subunits Camps, Montserrat; Hou, Cuifen; Sidiropoulos, Dimitrios European Journal of Biochemistry, Vol. 206, Issue 3 https://doi.org/10.1111/j.1432-1033.1992.tb16990.x	journal	June 1992
Dissection of the Steps of Phospholipase Cβ ₂ Activity That Are Enhanced by Gβγ Subunits ^† Feng, Jianwen; Roberts, Mary F.; Drin, Guillaume Biochemistry, Vol. 44, Issue 7 https://doi.org/10.1021/bi0482607	journal	February 2005
Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits Wing, Michele R.; Houston, Dayle; Kelley, Grant G. Journal of Biological Chemistry, Vol. 276, Issue 51 https://doi.org/10.1074/jbc.C100574200	journal	October 2001
Mammalian Phospholipase C Kadamur, Ganesh; Ross, Elliott M. Annual Review of Physiology, Vol. 75, Issue 1 https://doi.org/10.1146/annurev-physiol-030212-183750	journal	February 2013
Phospholipase C isozymes as effectors of Ras superfamily GTPases Harden, T. Kendall; Hicks, Stephanie N.; Sondek, John Journal of Lipid Research, Vol. 50, Issue Supplement https://doi.org/10.1194/jlr.R800045-JLR200	journal	November 2008
Membrane Binding of Phospholipases C-β ₁ and C-β ₂ Is Independent of Phosphatidylinositol 4,5-Bisphosphate and the α and βγ Subunits of G Proteins ^† Runnels, Loren W.; Jenco, John; Morris, Andrew Biochemistry, Vol. 35, Issue 51 https://doi.org/10.1021/bi961606w	journal	January 1996
Phospholipase Cɛ links G protein-coupled receptor activation to inflammatory astrocytic responses Dusaban, Stephanie S.; Purcell, Nicole H.; Rockenstein, Edward Proceedings of the National Academy of Sciences, Vol. 110, Issue 9 https://doi.org/10.1073/pnas.1217355110	journal	February 2013
Structural and Mechanistic Insights into Ras Association Domains of Phospholipase C Epsilon Bunney, Tom D.; Harris, Richard; Gandarillas, Natalia Lamuño Molecular Cell, Vol. 21, Issue 4 https://doi.org/10.1016/j.molcel.2006.01.008	journal	February 2006
Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex Waldo, G. L.; Ricks, T. K.; Hicks, S. N. Science, Vol. 330, Issue 6006 https://doi.org/10.1126/science.1193438	journal	October 2010
Phospholipase Cepsilon: a novel Ras effector Kelley, G. G. The EMBO Journal, Vol. 20, Issue 4 https://doi.org/10.1093/emboj/20.4.743	journal	February 2001

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