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Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET

Journal Article · · Molecular Imaging
 [1];  [1];  [2];  [1]
  1. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
  2. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA

Positron emission tomography (PET) imaging with biological macromolecules greatly expands the possibilities of molecular imaging. There are, however, practical aspects limiting the potential of the approach, including the dosimetric consequences of the slow kinetics of radiolabeled biomacromolecules. Pretargeting strategies have led to impactful improvements in the field but are themselves limited by shortcomings of available bioconjugation methodology. We report our initial findings concerning the suitability of the adamantane/cucurbit[7]uril system for pretargeted immuno-PET imaging and provide proof-of-concept PET/computed tomography imaging experiments to establish the stability and rapid formation of host–guest complexes in vivo. The adamantane/cucurbit[7]uril system itself without antibody conjugation has shown remarkably fast association kinetics and clearance in vivo. We further demonstrate the modulation of biodistribution achievable by cucurbituril complexation with relevance for pharmaceutical formulation as well as the radiosynthetic access to relevant reporter molecules labeled with 11C or 18F. This work, an early proof-of-concept, supports the notion that the adamantane/cucurbit[7]uril system warrants further exploration in pretargeted PET imaging applications.

Sponsoring Organization:
USDOE Office of Science (SC); National Science Foundation (NSF)
Grant/Contract Number:
SC0008430
OSTI ID:
1479126
Alternate ID(s):
OSTI ID: 1611050
Journal Information:
Molecular Imaging, Journal Name: Molecular Imaging Vol. 17; ISSN 1536-0121
Publisher:
SAGECopyright Statement
Country of Publication:
Country unknown/Code not available
Language:
English

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