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Title: Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop

Journal Article · · Nature Communications

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
NIHNIAID
OSTI ID:
1476094
Journal Information:
Nature Communications, Vol. 9, Issue 1; ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

References (36)

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability journal May 2017
Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses journal May 2017
Synergistic drug combination effectively blocks Ebola virus infection journal January 2017
Overview of the CCP 4 suite and current developments journal March 2011
The LANL hemorrhagic fever virus database, a new platform for analyzing biothreat viruses journal November 2011
Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site journal May 2016
FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection journal June 2013
Structures of protective antibodies reveal sites of vulnerability on Ebola virus journal November 2014
Coot model-building tools for molecular graphics journal November 2004
Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection journal June 2016
Toremifene interacts with and destabilizes the Ebola virus glycoprotein journal June 2016
Possible FDA-approved drugs to treat Ebola virus infection journal May 2015
Viral membrane fusion journal May 2015
Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein journal October 2015
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Structures of Ebola virus GP and sGP in complex with therapeutic antibodies journal August 2016
A shared structural solution for neutralizing ebolaviruses journal November 2011
Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1 journal January 2016
PHENIX : building new software for automated crystallographic structure determination journal October 2002
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody journal May 2016
The Primed Ebolavirus Glycoprotein (19-Kilodalton GP1,2): Sequence and Residues Critical for Host Cell Binding journal January 2009
Virus Variation Resource – improved response to emergent viral outbreaks journal November 2016
Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity journal September 2017
Human Adaptation of Ebola Virus during the West African Outbreak journal November 2016
Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic journal November 2016
Ebolavirus Entry Requires a Compact Hydrophobic Fist at the Tip of the Fusion Loop journal April 2014
Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor journal July 2008
XDS journal January 2010
Inference of Macromolecular Assemblies from Crystalline State journal September 2007
Structural and molecular basis for Ebola virus neutralization by protective human antibodies journal February 2016
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability journal November 2016
WebLogo: A Sequence Logo Generator journal May 2004
Crystal Structure of the Ebola Virus Membrane Fusion Subunit, GP2, from the Envelope Glycoprotein Ectodomain journal November 1998
Biochemical and Structural Characterization of Cathepsin L-Processed Ebola Virus Glycoprotein: Implications for Viral Entry and Immunogenicity journal January 2010
Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection journal January 2018
Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model journal June 2017