Neuroprotection of rhGLP‐1 in diabetic rats with cerebral ischemia/reperfusion injury via regulation of oxidative stress, EAAT2, and apoptosis

Fang, Yi; Jiang, Daoli; Wang, Yitong; Wang, Qian; Lv, Dongmei; Liu, Jichao; Liu, Chang

doi:10.1002/ddr.21439

Neuroprotection of rhGLP‐1 in diabetic rats with cerebral ischemia/reperfusion injury via regulation of oxidative stress, EAAT2, and apoptosis

Journal Article · Mon Sep 17 00:00:00 EDT 2018 · Drug Development Research

DOI:https://doi.org/10.1002/ddr.21439· OSTI ID:1472157

Fang, Yi ^[1]; ^[2]; Wang, Yitong ^[3]; Wang, Qian ^[1]; Lv, Dongmei ^[2]; Liu, Jichao ^[4]; Liu, Chang ^[5]

Department of Pharmacy Peking University People's Hospital Beijing People's Republic of China
Department of Pharmacy The Affiliated Hospital of Xuzhou Medical University Xuzhou People's Republic of China
Department of Pharmacy Peking University People's Hospital Beijing People's Republic of China, Department of Pharmacy Administration and Clinical Pharmacy Peking University Health Science Center Beijing People's Republic of China
Animal Experimental Center Peking University People's Hospital Beijing People's Republic of China
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University Xuzhou People's Republic of China

Preclinical Research & Development

The purpose of the present study is to evaluate the neuroprotective effect of recombinant human glucagon‐like peptide‐1 (rhGLP‐1) as well as to explore corresponding mechanisms in diabetic rats with cerebral ischemia/reperfusion injury induced by middle cerebral artery occlusion (MCAO). Diabetes mellitus was induced by intraperitoneal injection of streptozotocin. The rats were pretreated with rhGLP‐1 (20 μg/kg intraperitoneally, thrice a day) for 14 days. Thereafter, the rats were subjected to MCAO 90 min/reperfusion 24 hr. At 2 and 24 hr of reperfusion, the rats were assessed for neurological deficits and subsequently executed for the evaluation of cerebral infarct volume, oxidative stress parameters, and the expression of excitatory amino acid transporter 2 (EAAT2) and apoptotic markers. Results indicate that rhGLP‐1 significantly ameliorated neurological deficits and reduced cerebral infarct volume in diabetic MCAO rats. In addition, oxidative stress parameters in ischemic penumbra were significantly alleviated in rhGLP‐1‐pretreated diabetic MCAO rats. rhGLP‐1 significantly upregulated the ratio of Bcl‐2/Bax and EAAT2 expression and downregulated cleaved caspase‐3 expression in ischemic penumbra of diabetic MCAO rats. Our results suggest that rhGLP‐1 could significantly ameliorate neurological deficits and reduce cerebral infarct volume in diabetic MCAO rats, which may be due to the inhibition of oxidative stress and apoptosis and the promotion of EAAT2 expression.

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

OSTI ID:: 1472157

Journal Information:: Drug Development Research, Journal Name: Drug Development Research Journal Issue: 6 Vol. 79; ISSN 0272-4391

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

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