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Title: Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications

Journal Article · · Journal of Nanoparticle Research
ORCiD logo [1];  [1]; ORCiD logo [2]; ORCiD logo [2];  [1]
  1. Virginia Commonwealth Univ., Richmond, VA (United States). Dept. of Mechanical and Nuclear Engineering
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division
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Lanthanide phosphate nanomaterials are appealing as multifunctional platforms for biomedical applications because of their low toxicity, radiation resistance, and unique luminescence and magnetic properties. Lanthanide phosphate nanoparticles (NPs) radiolabeled with 156Eu were synthesized by an aqueous route using sodium tripolyphosphate as a phosphate source and complexing agent. GdPO4 was used as a host matrix, while synthetic concentrations of Ce3+/Tb3+ and Eu3+ were varied between 5–40% and 10–30%, respectively, and yielded spherical NPs with hexagonal crystal system and particle size < 5 nm. Luminescence emission and magnetic susceptibility were influenced by lanthanide concentrations where characteristic 5D0-7FJ and 5D4-7FJ transitions were observed for Eu3+- and Tb3+-doped NPs, respectively. Chemical yield of > 90% was achieved for GdPO4 and Gd0.6Ce0.3Tb0.1PO4 NPs intrinsically radiolabeled with 156Eu. Lastly, in vitro retention of 156Eu within LnPO4 NPs was > 97% over 3 weeks. Intrinsically radiolabeled LnPO4 NPs have the potential to combine the luminescence and magnetic properties of Ln3+ ions with lanthanide radioisotopes for biomedical and environmental applications.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1471921
Journal Information:
Journal of Nanoparticle Research, Vol. 20, Issue 9; ISSN 1388-0764
Publisher:
Tsinghua University PressCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 10 works
Citation information provided by
Web of Science

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  • Jolley, Kenny; Asuvathraman, Rajaram; Smith, Roger
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 393 https://doi.org/10.1016/j.nimb.2016.10.016
journal February 2017
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Cited By (2)

Gadolinium vanadate nanocrystals as carriers of α-emitters ( 225 Ac, 227 Th) and contrast agents journal June 2019
Prediction of new iodine-containing apatites using machine learning and density functional theory journal August 2019

Figures / Tables (24)

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Related Subjects

36 MATERIALS SCIENCE
77 NANOSCIENCE AND NANOTECHNOLOGY
Multifunctional nanomaterials
lanthanide phosphate
luminescence
magnetic susceptibility
intrinsically radiolabeled nanoparticles
europium-156