A “cross-stitched” peptide with improved helicity and proteolytic stability
Journal Article
·
· Organic and Biomolecular Chemistry
[1];
[2];
[3];
[1];
[4];
[3];
[1]
- Department of Medicinal Chemistry and Pharmacognosy and UI Cancer Center; University of Illinois at Chicago; Chicago; USA
- Department of Biochemistry and Beckman Institute for Advanced Science and Technology; The University of Illinois at Urbana-Champaign; Urbana; USA; C.G.M. is now affiliated with the Celgene Corporation
- The Ben May Department for Cancer Research; The University of Chicago; Chicago; USA
- Department of Biochemistry and Beckman Institute for Advanced Science and Technology; The University of Illinois at Urbana-Champaign; Urbana; USA
Peptide “cross-stitching” maintains binding affinity and can enhance helical and proteolytic stability.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- National Institutes of Health (NIH)
- OSTI ID:
- 1467698
- Journal Information:
- Organic and Biomolecular Chemistry, Vol. 16, Issue 20; ISSN 1477-0520
- Publisher:
- Royal Society of Chemistry
- Country of Publication:
- United States
- Language:
- ENGLISH
Similar Records
Origin of Proteolytic Stability of Peptide-Brush Polymers as Globular Proteomimetics
Peptide design by optimization on a data-parameterized protein interaction landscape
Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells
Journal Article
·
Thu Dec 02 00:00:00 EST 2021
· ACS Central Science
·
OSTI ID:1467698
+8 more
Peptide design by optimization on a data-parameterized protein interaction landscape
Journal Article
·
Mon Oct 15 00:00:00 EDT 2018
· Proceedings of the National Academy of Sciences of the United States of America
·
OSTI ID:1467698
+3 more
Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells
Journal Article
·
Tue Jan 16 00:00:00 EST 2018
· Proceedings of the National Academy of Sciences of the United States of America
·
OSTI ID:1467698
+7 more