Enzymatically triggered rupture of polymersomes

Jang, Woo-Sik; Park, Seung Chul; Reed, Ellen H.; Dooley, Kevin P.; Wheeler, Samuel F.; Lee, Daeyeon; Hammer, Daniel A.

doi:10.1039/c5sm01881a

Enzymatically triggered rupture of polymersomes

Journal Article · Fri Nov 11 00:00:00 EST 2016 · Soft Matter

DOI:https://doi.org/10.1039/c5sm01881a· OSTI ID:1467656

Jang, Woo-Sik ^[1]; Park, Seung Chul ^[2]; Reed, Ellen H. ^[2]; Dooley, Kevin P. ^[3]; Wheeler, Samuel F. ^[4]; Lee, Daeyeon ^[2]; Hammer, Daniel A. ^[2]

Univ. of Pennsylvania, Philadelphia, PA (United States); University of Pennsylvania
Univ. of Pennsylvania, Philadelphia, PA (United States)
Rowan Univ., Glassboro, NJ (United States)
Harriton High School; Rosemont, PA, (United States)

Polymersomes are robust vesicles made from di-block co-polymers. We have engineered a two step enzymatic cascade to trigger the release of contents from polymersomes, in which extravesicular glucose oxidase makes hydrogen peroxide, when then penetrates the membrane and is converted by entrapped catalase to oxygen, leading to vesicle failure.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Pennsylvania, Philadelphia, PA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0007063

OSTI ID:: 1467656

Journal Information:: Soft Matter, Journal Name: Soft Matter Journal Issue: 4 Vol. 12; ISSN SMOABF; ISSN 1744-683X

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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