Mathematical modeling of within-host Zika virus dynamics

Best, Katharine; Perelson, Alan S.

doi:10.1111/imr.12687

Mathematical modeling of within-host Zika virus dynamics

Journal Article · Sat Aug 11 00:00:00 EDT 2018 · Immunological Reviews

DOI:https://doi.org/10.1111/imr.12687· OSTI ID:1467343

Best, Katharine ^[1]; ^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Recent Zika virus outbreaks have been associated with severe outcomes, especially during pregnancy. A great deal of effort has been put toward understanding this virus, particularly the immune mechanisms responsible for rapid viral control in the majority of infections. Identifying and understanding the key mechanisms of immune control will provide the foundation for the development of effective vaccines and antiviral therapy. In this paper, we outline a mathematical modeling approach for analyzing the within-host dynamics of Zika virus, and we describe how these models can be used to understand key aspects of the viral life cycle and to predict antiviral efficacy.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL)

Sponsoring Organization:: National Inst. of Health (NIH) (United States); USDOE

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1467343

Report Number(s):: LA-UR-18-24074

Journal Information:: Immunological Reviews, Journal Name: Immunological Reviews Journal Issue: 1 Vol. 285; ISSN 0105-2896

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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