Nematic-like stable glasses without equilibrium liquid crystal phases

Gómez, Jaritza; Gujral, Ankit; Huang, Chengbin; Bishop, Camille; Yu, Lian; Ediger, M. D.

doi:10.1063/1.4974829

Title: Nematic-like stable glasses without equilibrium liquid crystal phases

Journal Article · Thu Feb 02 00:00:00 EST 2017 · Journal of Chemical Physics

DOI:https://doi.org/10.1063/1.4974829· OSTI ID:1465678

Gómez, Jaritza ^[1];

^[1]; Huang, Chengbin ^[2];

^[1]; Yu, Lian ^[2];

^[1]

Univ. of Wisconsin, Madison, WI (United States). Dept. of Chemistry
Univ. of Wisconsin, Madison, WI (United States). School of Pharmacy

In this paper, we report the thermal and structural properties of glasses of posaconazole, a rod-like molecule, prepared using physical vapor deposition (PVD). PVD glasses of posaconazole can show substantial molecular orientation depending upon the choice of substrate temperature, T_substrate, during deposition. Ellipsometry and IR measurements indicate that glasses prepared at T_substrate very near the glass transition temperature (T_g) are highly ordered. For these posaconazole glasses, the orientation order parameter is similar to that observed in macroscopically aligned nematic liquid crystals, indicating that the molecules are mostly parallel to one another and perpendicular to the interface. To our knowledge, these are the most anisotropic glasses ever prepared by PVD from a molecule that does not form equilibrium liquid crystal phases. These results are consistent with a previously proposed mechanism in which molecular orientation in PVD glasses is inherited from the orientation present at the free surface of the equilibrium liquid. This mechanism suggests that molecular orientation at the surface of the equilibrium liquid of posaconazole is nematic-like. Posaconazole glasses can show very high kinetic stability; the isothermal transformation of a 400 nm glass into the supercooled liquid occurs via a propagating front that originates at the free surface and requires ~10⁵ times the structural relaxation time of the liquid (τ_α). We also studied the kinetic stability of PVD glasses of itraconazole, which is a structurally similar molecule with equilibrium liquid crystal phases. Finally, while itraconazole glasses can be even more anisotropic than posaconazole glasses, they exhibit lower kinetic stability.

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Research Organization:: Univ. of Wisconsin, Madison, WI (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Science Foundation (NSF)

Grant/Contract Number:: SC0002161; DMR-1234320; DMR-1121288

OSTI ID:: 1465678

Alternate ID(s):: OSTI ID: 1361753

Journal Information:: Journal of Chemical Physics, Vol. 146, Issue 5; ISSN 0021-9606

Publisher:: American Institute of Physics (AIP)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 17 works

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Generic packing motifs in vapor-deposited glasses of organic semiconductors Bagchi, Kushal; Gujral, Ankit; Toney, M. F. Soft Matter, Vol. 15, Issue 38 https://doi.org/10.1039/c9sm01155b	journal	January 2019
Tenfold increase in the photostability of an azobenzene guest in vapor-deposited glass mixtures Qiu, Yue; Antony, Lucas W.; Torkelson, John M. The Journal of Chemical Physics, Vol. 149, Issue 20 https://doi.org/10.1063/1.5052003	journal	November 2018
Vapor deposition of a nonmesogen prepares highly structured organic glasses Bishop, Camille; Thelen, Jacob L.; Gann, Eliot Proceedings of the National Academy of Sciences, Vol. 116, Issue 43 https://doi.org/10.1073/pnas.1908445116	journal	September 2019
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