Modifying the strength and strain concentration profile within collagen scaffolds using customizable arrays of poly-lactic acid fibers

Mozdzen, Laura C.; Vucetic, Alan; Harley, Brendan A. C.

doi:10.1016/j.jmbbm.2016.10.017

Title: Modifying the strength and strain concentration profile within collagen scaffolds using customizable arrays of poly-lactic acid fibers

Journal Article · Thu Oct 27 00:00:00 EDT 2016 · Journal of the Mechanical Behavior of Biomedical Materials

DOI:https://doi.org/10.1016/j.jmbbm.2016.10.017· OSTI ID:1465177

Mozdzen, Laura C. ^[1]; Vucetic, Alan ^[1]; Harley, Brendan A. C. ^[1]

Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States)

Here, the tendon-to-bone junction is a highly specialized tissue which dissipates stress concentrations between mechanically dissimilar tendon and bone. Upon injury, the local heterogeneities across this insertion are not regenerated, leading to poor functional outcomes such as formation of scar tissue at the insertion and re-failure rates exceeding 90%. Although current tissue engineering methods are moving towards the development of spatially-graded biomaterials to begin to address these injuries, significant opportunities remain to engineer the often complex local mechanical behavior of such biomaterials to enhance their bioactivity. Here, we describe the use of three-dimensional printing techniques to create customizable arrays of poly-lactic acid (PLA) fibers that can be incorporated into a collagen scaffold under development for tendon bone junction repair. Notably, we use additive manufacturing concepts to generate arrays of spatially-graded fibers from biodegradable PLA that are incorporated into collagen scaffolds to create a collagen-PLA composite. We demonstrate the ability to tune the mechanical performance of the fiber-scaffold composite at the bulk scale. We also demonstrate the incorporation of spatially-heterogeneous fiber designs to establish non-uniform local mechanical performance of the composite biomaterial under tensile load, a critical element in the design of multi-compartment biomaterials for tendon-to-bone regeneration applications. Together, this work highlights the capacity to use multi-scale composite biomaterials to control local and bulk mechanical properties, and provides key insights into design elements under consideration for mechanically competent, multi-tissue regeneration platforms.

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Research Organization:: Univ. of Illinois Urbana-Champaign, Urbana, IL (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: FG02-07ER46453; FG02-07ER46471

OSTI ID:: 1465177

Alternate ID(s):: OSTI ID: 1398669

Journal Information:: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 66, Issue C; ISSN 1751-6161

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 20 works

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