Kinetics of the Same Reaction Monitored over Nine Orders of Magnitude in Concentration: When Are Unique Subensemble and Single-Turnover Reactivity Displayed?

Easter, Quinn T.; Blum, Suzanne A.

doi:10.1002/anie.201807317

Title: Kinetics of the Same Reaction Monitored over Nine Orders of Magnitude in Concentration: When Are Unique Subensemble and Single-Turnover Reactivity Displayed?

Journal Article · Sun Jul 01 00:00:00 EDT 2018 · Angewandte Chemie (International Edition)

DOI:https://doi.org/10.1002/anie.201807317· OSTI ID:1836115

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Univ. of California, Irvine, CA (United States)

Abstract Essentially no information is known about the behavior of individual molecular catalysts under reaction conditions. This is a result of the averaging inherent to traditional analytical techniques. Herein, a combined fluorescence microscopy and ¹ H NMR spectroscopy study reveals that unique (that is, non‐ensemble averaged) distributions and time‐variable kinetics from molecular ruthenium catalysts within growing polynorbornene occur and are detectable between 10 ⁻⁹ m and 10 ⁻⁶ m of substrate, surprisingly just 1000‐fold less concentrated than a typical laboratory bench‐scale reaction. The kinetic states governing single‐turnover events are determinable by overlay of the signal arising from individual monomer insertion reactions with that from polymer growth from neighboring catalysts.

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Research Organization:: Univ. of California, Irvine, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0016467

OSTI ID:: 1836115

Alternate ID(s):: OSTI ID: 1463361

Journal Information:: Angewandte Chemie (International Edition), Vol. 57, Issue 37; ISSN 1433-7851

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 16 works

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Sialic acid–targeted drug delivery and imaging system for pH- and glutathione-triggered multiple anticancer drug release and enhanced oxidative stress Peng, Licong; Zeng, Xianwu; Qi, Qianqian Journal of Bioactive and Compatible Polymers, Vol. 35, Issue 3 https://doi.org/10.1177/0883911520913913	journal	April 2020

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Title: Kinetics of the Same Reaction Monitored over Nine Orders of Magnitude in Concentration: When Are Unique Subensemble and Single-Turnover Reactivity Displayed?

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