Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation
- Univ. of Rochester, NY (United States). School of Medicine and Dentistry and Dept. of Neuroscience; OSTI
- Univ. of Rochester, NY (United States). School of Medicine and Dentistry and Dept. of Neuroscience
- Univ. of Rochester, NY (United States). School of Medicine and Dentistry, Dept. of Radiation Oncology and Dept. of Environmental Medicine
- Univ. of Rochester, NY (United States). School of Medicine and Dentistry and Dept. of Neuroscience and Neurology
Understanding the dose-toxicity profile of radiation is critical when evaluating potential health risks associated with natural and man-made sources in our environment. This study was done to evaluate the effects of low-dose whole-body high-energy charged (HZE) iron (Fe) ions and low-energy gamma exposure on proliferation and differentiation of adult-born neurons within the dentate gyrus of the hippocampus, cells deemed to play a critical role in memory regulation. To determine the dose-response characteristics of the brain to whole-body Fe-ion vs. gamma-radiation exposure, C57BL/6J mice were irradiated with 1 GeV/n Fe ions or a static 137Cs source (0.662 MeV) at doses ranging from 0 to 300 cGy. The neurogenesis was analyzed at 48 h and one month postirradiation. These experiments revealed that whole-body exposure to either Fe ions or gamma radiation leads to: 1. An acute decrease in cell division within the dentate gyrus of the hippocampus, detected at doses as low as 30 and 100 cGy for Fe ions and gamma radiation, respectively; and 2. A reduction in newly differentiated neurons (DCX immunoreactivity) at one month postirradiation, with significant decreases detected at doses as low as 100 cGy for both Fe ions and gamma rays. The data presented here contribute to our understanding of brain responses to whole-body Fe ions and gamma rays and may help inform health-risk evaluations related to systemic exposure during a medical or radiologic/nuclear event or as a result of prolonged space travel.
- Research Organization:
- Univ. of Rochester, NY (United States)
- Sponsoring Organization:
- National Aeronautic and Space Administration (NASA); National Inst. of Health (NIH); USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23). Biological Systems Science Division
- Contributing Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Grant/Contract Number:
- FG02-07ER64338
- OSTI ID:
- 1463107
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 6 Vol. 186; ISSN 0033-7587
- Publisher:
- Radiation Research SocietyCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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