Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease

Journal Article · · Scientific Reports
Abstract not provided.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
NIH
OSTI ID:
1462573
Journal Information:
Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 7; ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

References (43)

Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors journal May 2007
Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site journal February 2009
Refinement of Macromolecular Structures by the Maximum-Likelihood Method journal May 1997
Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease journal August 2012
Fragment-Based Identification of Influenza Endonuclease Inhibitors journal June 2016
Phenyl Substituted 4-Hydroxypyridazin-3(2 H )-ones and 5-Hydroxypyrimidin-4(3 H )-ones: Inhibitors of Influenza A Endonuclease journal September 2014
N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes journal August 2016
Features and development of Coot journal March 2010
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Recent Advances in Computer-Aided Drug Design as Applied to Anti-Influenza Drug Discovery journal October 2014
Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection journal September 2008
Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. journal December 1994
Discovery and Synthesis of HIV Integrase Inhibitors:  Development of Potent and Orally Bioavailable N-Methyl Pyrimidones journal October 2007
Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor journal March 2016
Antivirals for influenza: Historical perspectives and lessons learned journal September 2006
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1 journal March 2001
Multinational Impact of the 1968 Hong Kong Influenza Pandemic: Evidence for a Smoldering Pandemic journal July 2005
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus journal October 2015
Phaser crystallographic software journal July 2007
Structure of influenza A polymerase bound to the viral RNA promoter journal November 2014
WHO recommendations for the viruses used in the 2013–2014 Northern Hemisphere influenza vaccine: Epidemiology, antigenic and genetic characteristics of influenza A(H1N1)pdm09, A(H3N2) and B influenza viruses collected from October 2012 to January 2013 journal August 2014
A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro journal July 2016
Integrating historical, clinical and molecular genetic data in order to explain the origin and virulence of the 1918 Spanish influenza virus
  • Taubenberger, Jeffery K.; Reid, Ann H.; Janczewski, Thomas A.
  • Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 356, Issue 1416 https://doi.org/10.1098/rstb.2001.1020
journal December 2001
Current and novel antiviral strategies for influenza infection journal June 2016
Structural and computational study on inhibitory compounds for endonuclease activity of influenza virus polymerase journal September 2015
Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives journal February 2017
Identification of Influenza Endonuclease Inhibitors Using a Novel Fluorescence Polarization Assay journal January 2012
Global Mortality Impact of the 1957–1959 Influenza Pandemic journal February 2016
When poor solubility becomes an issue: From early stage to proof of concept journal August 2007
Strategies of Development of Antiviral Agents Directed Against Influenza Virus Replication journal December 2007
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit journal February 2009
Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2 journal July 2014
Use of a Pharmacophore Model To Discover a New Class of Influenza Endonuclease Inhibitors journal March 2003
Favipiravir: A New Medication for the Ebola Virus Disease Pandemic journal December 2014
3-Hydroxyquinolin-2(1 H )-ones As Inhibitors of Influenza A Endonuclease journal May 2013
The 1918 Spanish influenza:integrating history and biology journal January 2001
2-Substituted-4,5-Dihydroxypyrimidine-6-Carboxamide Antiviral Targeted Libraries journal November 2009
PA subunit of RNA polymerase as a promising target for anti-influenza virus agents journal June 2008
Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit journal December 2014
Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit journal April 2016
Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors journal September 2013
Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase journal August 2012
Synthesis of Natural Flutimide and Analogous Fully Substituted Pyrazine-2,6-diones, Endonuclease Inhibitors of Influenza Virus journal August 2001

Similar Records

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease
Journal Article · Sun Mar 03 23:00:00 EST 2013 · PLoS Patho. · OSTI ID:1061306

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes
Journal Article · Thu Aug 11 00:00:00 EDT 2016 · Scientific Reports · OSTI ID:1298278

Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors
Journal Article · Mon Aug 31 00:00:00 EDT 2020 · ACS Medicinal Chemistry Letters · OSTI ID:1657581

Related Subjects