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Title: Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities

Journal Article · · Journal of Biological Chemistry

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
National Institutes of Health (NIH)
OSTI ID:
1462568
Journal Information:
Journal of Biological Chemistry, Vol. 292, Issue 44; ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology
Country of Publication:
United States
Language:
ENGLISH

References (33)

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The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts journal July 2007
Coot model-building tools for molecular graphics journal November 2004
Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation journal March 2012
A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase journal July 2015
The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization journal September 2002
Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB journal January 2011
IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family journal June 2014
Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death journal April 2013
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The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis journal January 2017
Ionization Properties of Phosphatidylinositol Polyphosphates in Mixed Model Membranes journal October 2009
Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast journal August 2005
Crystal Structure of the Catalytic Core of Inositol 1,4,5-Trisphosphate 3-Kinase journal September 2004
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A Role for Rat Inositol Polyphosphate Kinases rIPK2 and rIPK1 in Inositol Pentakisphosphate and Inositol Hexakisphosphate Production in Rat-1 Cells journal November 2004
Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase journal February 2011
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Huntington’s disease: Neural dysfunction linked to inositol polyphosphate multikinase journal July 2015
A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control journal March 2000
Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease journal June 2016
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity journal August 2005
Inositol Pentakisphosphate Mediates Wnt/β-Catenin Signaling journal June 2007
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase journal March 2002
Inositol phosphate metabolomics: Merging genetic perturbation with modernized radiolabeling methods journal June 2006
Recruitment of the yeast MADS-box proteins, ArgRI and Mcm1 by the pleiotropic factor ArgRIII is required for their stability journal January 2000
PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis journal January 2017
Human Inositol Polyphosphate Multikinase Regulates Transcript-Selective Nuclear mRNA Export to Preserve Genome Integrity journal September 2013
AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase journal December 2011

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